Does contrast ultrasound dispersion imaging reveal changes in tortuosity? : a comparison with acoustic angiography

A. Panfilova, M. Mischi, H. Wijkstra, R.J.G. van Sloun, L. Demi, S. Shelton, P. Dayton

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Higher microvascular density with tortuous and irregular vessels are hallmarks of cancer vasculature. These alterations can be captured by contrast ultrasound dispersion imaging (CUDI) and acoustic angiography (AA) at different scales: CUDI aims at obtaining an implicit measure of structural alteration by determining the dispersion kinetics of contrast agents. At a smaller scale, AA images the vascular architecture by detecting the high-frequency components generated with ultrasound contrast agents (UCA). This work shows the performance of these techniques by imaging cancerous and control regions in 3 rat xenograft models. Furthermore, it investigates the diagnostic value of the vascular features extracted using CUDI and AA with the aim to answer the question: does CUDI reveal changes in vascular tortuosity?
Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium (IUS)
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Number of pages4
Publication statusPublished - 2016
Event2016 IEEE International Ultrasonics Symposium (IUS 2016) - Convention Center Vinci, Tours, France
Duration: 18 Sept 201621 Sept 2016


Conference2016 IEEE International Ultrasonics Symposium (IUS 2016)
Abbreviated titleIUS 2016
Internet address


  • Cancer, Acoustic angiography,
  • Contrastenhanced


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