DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

M.G. Debije; M.T. Milano; W.A. Bernhard

doi:10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

M.G. Debije
, M.T. Milano
, W.A. Bernhard

Research output: Contribution to journal › Article › Academic › peer-review

74 Citations (Scopus)

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Abstract

The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

Original language	English
Pages (from-to)	2752-2756
Journal	Angewandte Chemie - International Edition
Volume	38
Issue number	18
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U
Publication status	Published - 1999

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10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

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title = "DNA responds to ionizing radiation as an insulator, not as a {"}molecular wire{"}",

abstract = "The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a {"}molecular wire{"}.",

author = "M.G. Debije and M.T. Milano and W.A. Bernhard",

year = "1999",

doi = "10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U",

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TY - JOUR

T1 - DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

AU - Debije, M.G.

AU - Milano, M.T.

AU - Bernhard, W.A.

PY - 1999

Y1 - 1999

N2 - The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

AB - The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

U2 - 10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

DO - 10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

M3 - Article

SN - 0570-0833

VL - 38

SP - 2752

EP - 2756

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 18

ER -

DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

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