DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

M.G. Debije, M.T. Milano, W.A. Bernhard

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

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Ionizing radiation
DNA
Wire
Paramagnetic resonance
Oligodeoxyribonucleotides
Single crystals
Spectroscopy
Crystals

Cite this

@article{a96f8518f922457b851d5c3cb94ef915,
title = "DNA responds to ionizing radiation as an insulator, not as a {"}molecular wire{"}",
abstract = "The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a {"}molecular wire{"}.",
author = "M.G. Debije and M.T. Milano and W.A. Bernhard",
year = "1999",
doi = "10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U",
language = "English",
volume = "38",
pages = "2752--2756",
journal = "Angewandte Chemie - International Edition",
issn = "0570-0833",
publisher = "Wiley",
number = "18",

}

DNA responds to ionizing radiation as an insulator, not as a "molecular wire". / Debije, M.G.; Milano, M.T.; Bernhard, W.A.

In: Angewandte Chemie - International Edition, Vol. 38, No. 18, 1999, p. 2752-2756.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - DNA responds to ionizing radiation as an insulator, not as a "molecular wire"

AU - Debije,M.G.

AU - Milano,M.T.

AU - Bernhard,W.A.

PY - 1999

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N2 - The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

AB - The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol¿J-1) and insensitive to long-range (>106 base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

U2 - 10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

DO - 10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U

M3 - Article

VL - 38

SP - 2752

EP - 2756

JO - Angewandte Chemie - International Edition

T2 - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 0570-0833

IS - 18

ER -