DNA-coatings: Bioactive properties and effects on osteoblast-like cells

J.J.J.P. Beucken, van den, X.F. Walboomers, S.G.G. Leeuwenburgh, M.R.J. Vos, N.A.J.M. Sommerdijk, R.J.M. Nolte, J.A. Jansen

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Abstract

The aim of this study was to evaluate potential effects of DNA-coatings on calcium phosphate (CaP) nucleation from simulated body fluids (SBF) and subsequently the effects of DNA-coatings and SBF-immersed DNA coatings on the behavior of osteoblast-like cells. DNAcoatings demonstrated to enhance the nucleation and deposition of CaP from SBF compared to titanium controls. The behavior of osteoblast-like cells was affected on SBF-immersed DNAcoatings, showing an increased deposition of the extracellular matrix protein osteocalcin compared to titanium controls. These results indicate bone-bonding capacity of DNA-coatings, which needs to be confirmed using future animal experiments.
Original languageEnglish
Pages (from-to)605-608
JournalKey Engineering Materials
Volume361-363
Publication statusPublished - 2008

Keywords

  • DNA-coating
  • mineral deposition
  • calcium phosphate
  • SBF
  • cell culture

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