Abstract
The aim of this study was to evaluate potential effects of DNA-coatings on calcium
phosphate (CaP) nucleation from simulated body fluids (SBF) and subsequently the effects of
DNA-coatings and SBF-immersed DNA coatings on the behavior of osteoblast-like cells. DNAcoatings
demonstrated to enhance the nucleation and deposition of CaP from SBF compared to
titanium controls. The behavior of osteoblast-like cells was affected on SBF-immersed DNAcoatings,
showing an increased deposition of the extracellular matrix protein osteocalcin compared
to titanium controls. These results indicate bone-bonding capacity of DNA-coatings, which needs to
be confirmed using future animal experiments.
Original language | English |
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Pages (from-to) | 605-608 |
Journal | Key Engineering Materials |
Volume | 361-363 |
Publication status | Published - 2008 |
Keywords
- DNA-coating
- mineral deposition
- calcium phosphate
- SBF
- cell culture