A no. of 1-substituted imidazole-5-carboxylic acid esters (I) have been synthesized. Many of these are extremely potent, rapid, and short-acting hypnotic agents in rats.
Godefroi, E. F., Janssen, P. A. J., Van der Eycken, C. A. M., Van Heertum, A. H. M. T., & Niemegeers, C. J. E. (1965). DL-1-(1-arylalkyl)imidazole-5-carboxylate esters. A novel type of hypnotic agents. Journal of Medicinal Chemistry, 8(2), 220-223. https://doi.org/10.1021/jm00326a017