Diffusion-prepared stimulated-echo turbo spin echo (DPsti-TSE): An eddy current-insensitive sequence for three-dimensional high-resolution and undistorted diffusion-weighted imaging

Q. Zhang, B.F. Coolen, M.J. Versluis, G.J. Strijkers, A.J. Nederveen

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

In this study, we present a new three-dimensional (3D), diffusion-prepared turbo spin echo sequence based on a stimulated-echo read-out (DPsti-TSE) enabling high-resolution and undistorted diffusion-weighted imaging (DWI). A dephasing gradient in the diffusion preparation module and rephasing gradients in the turbo spin echo module create stimulated echoes, which prevent signal loss caused by eddy currents. Near to perfect agreement of apparent diffusion coefficient (ADC) values between DPsti-TSE and diffusion-weighted echo planar imaging (DW-EPI) was demonstrated in both phantom transient signal experiments and phantom imaging experiments. High-resolution and undistorted DPsti-TSE was demonstrated in vivo in prostate and carotid vessel wall. 3D whole-prostate DWI was achieved with four b values in only 6 min. Undistorted ADC maps of the prostate peripheral zone were obtained at low and high imaging resolutions with no change in mean ADC values [(1.60 ± 0.10) × 10−3 versus (1.60 ± 0.02) × 10−3 mm2/s]. High-resolution 3D DWI of the carotid vessel wall was achieved in 12 min, with consistent ADC values [(1.40 ± 0.23) × 10−3 mm2/s] across different subjects, as well as slice locations through the imaging volume. This study shows that DPsti-TSE can serve as a robust 3D diffusion-weighted sequence and is an attractive alternative to the traditional two-dimensional DW-EPI approaches.

Original languageEnglish
Article numbere3719
Number of pages12
JournalNMR in Biomedicine
Volume30
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • carotid imaging
  • diffusion-prepared TSE
  • DWI
  • eddy currents
  • prostate imaging
  • stimulated echo
  • Prostate/diagnostic imaging
  • Reproducibility of Results
  • Imaging, Three-Dimensional/methods
  • Humans
  • Middle Aged
  • Male
  • Carotid Arteries/diagnostic imaging
  • Young Adult
  • Algorithms
  • Sensitivity and Specificity
  • Adult
  • Female
  • Diffusion Magnetic Resonance Imaging/methods
  • Image Interpretation, Computer-Assisted/methods
  • Image Enhancement/methods

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