Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

E. Bergers, J.C.J. Bot, Paul van der Valk, J.A. Castelijns, G.J. Nijeholt, W. Kamphorst, C. Polman, E.L.A. Blezer, K. Nicolaij, R. Ravid, F. Barkhof

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Abstract

In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.
Original languageEnglish
Pages (from-to)652-656
JournalAnnals of Neurology
Volume51
Issue number5
DOIs
Publication statusPublished - 2002
Externally publishedYes

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