Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Emanuela Fioretta; Valentina Lintas; Anna Mallone; Sarah E. Motta; Lisa von Boehmer; Petra E. Dijkman; Nikola Cesarovic; Etem Caliskan; Hector Rodriguez Cetina Biefer; Miriam Lipiski; Mareike  Sauer; Matilde Putti; Henk M. Janssen; Serge H.M. Söntjens; Anthal I.P.M. Smits; Carlijn V.C. Bouten; M.Y. Emmert; Simon P. Hoerstrup

doi:10.1016/j.jacbts.2019.09.008

Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Emanuela Fioretta, Valentina Lintas, Anna Mallone, Sarah E. Motta, Lisa von Boehmer, Petra E. Dijkman, Nikola Cesarovic, Etem Caliskan, Hector Rodriguez Cetina Biefer, Miriam Lipiski, Mareike Sauer, Matilde Putti, Henk M. Janssen, Serge H.M. Söntjens, Anthal I.P.M. Smits, Carlijn V.C. Bouten, M.Y. Emmert (Corresponding author), Simon P. Hoerstrup (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.

Original language	English
Pages (from-to)	15-31
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	1
Early online date	11 Dec 2019
DOIs	https://doi.org/10.1016/j.jacbts.2019.09.008
Publication status	Published - 1 Jan 2020

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Keywords

cardiovascular regenerative medicine
endogenous tissue regeneration
in situ tissue engineering
supramolecular polymer
tissue-engineered heart valve

Cite this

Fioretta, E., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., ... Hoerstrup, S. P. (2020). Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements. JACC: Basic to Translational Science, 5(1), 15-31. https://doi.org/10.1016/j.jacbts.2019.09.008

Fioretta, Emanuela ; Lintas, Valentina ; Mallone, Anna ; Motta, Sarah E. ; von Boehmer, Lisa ; Dijkman, Petra E. ; Cesarovic, Nikola ; Caliskan, Etem ; Rodriguez Cetina Biefer, Hector ; Lipiski, Miriam ; Sauer, Mareike ; Putti, Matilde ; Janssen, Henk M. ; Söntjens, Serge H.M. ; Smits, Anthal I.P.M. ; Bouten, Carlijn V.C. ; Emmert, M.Y. ; Hoerstrup, Simon P. / Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements. In: JACC: Basic to Translational Science. 2020 ; Vol. 5, No. 1. pp. 15-31.

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title = "Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements",

abstract = "This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.",

keywords = "cardiovascular regenerative medicine, endogenous tissue regeneration, in situ tissue engineering, supramolecular polymer, tissue-engineered heart valve",

author = "Emanuela Fioretta and Valentina Lintas and Anna Mallone and Motta, {Sarah E.} and {von Boehmer}, Lisa and Dijkman, {Petra E.} and Nikola Cesarovic and Etem Caliskan and {Rodriguez Cetina Biefer}, Hector and Miriam Lipiski and Mareike Sauer and Matilde Putti and Janssen, {Henk M.} and S{\"o}ntjens, {Serge H.M.} and Smits, {Anthal I.P.M.} and Bouten, {Carlijn V.C.} and M.Y. Emmert and Hoerstrup, {Simon P.}",

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doi = "10.1016/j.jacbts.2019.09.008",

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Fioretta, E, Lintas, V, Mallone, A, Motta, SE, von Boehmer, L, Dijkman, PE, Cesarovic, N, Caliskan, E, Rodriguez Cetina Biefer, H, Lipiski, M, Sauer, M, Putti, M, Janssen, HM , Söntjens, SHM , Smits, AIPM , Bouten, CVC, Emmert, MY & Hoerstrup, SP 2020, 'Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements', JACC: Basic to Translational Science, vol. 5, no. 1, pp. 15-31. https://doi.org/10.1016/j.jacbts.2019.09.008

Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements. / Fioretta, Emanuela; Lintas, Valentina; Mallone, Anna; Motta, Sarah E.; von Boehmer, Lisa; Dijkman, Petra E.; Cesarovic, Nikola; Caliskan, Etem; Rodriguez Cetina Biefer, Hector; Lipiski, Miriam; Sauer, Mareike ; Putti, Matilde; Janssen, Henk M.; Söntjens, Serge H.M.; Smits, Anthal I.P.M.; Bouten, Carlijn V.C.; Emmert, M.Y. (Corresponding author); Hoerstrup, Simon P. (Corresponding author).

In: JACC: Basic to Translational Science, Vol. 5, No. 1, 01.01.2020, p. 15-31.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

AU - Fioretta, Emanuela

AU - Lintas, Valentina

AU - Mallone, Anna

AU - Motta, Sarah E.

AU - von Boehmer, Lisa

AU - Dijkman, Petra E.

AU - Cesarovic, Nikola

AU - Caliskan, Etem

AU - Rodriguez Cetina Biefer, Hector

AU - Lipiski, Miriam

AU - Sauer, Mareike

AU - Putti, Matilde

AU - Janssen, Henk M.

AU - Söntjens, Serge H.M.

AU - Smits, Anthal I.P.M.

AU - Bouten, Carlijn V.C.

AU - Emmert, M.Y.

AU - Hoerstrup, Simon P.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.

AB - This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.

KW - cardiovascular regenerative medicine

KW - endogenous tissue regeneration

KW - in situ tissue engineering

KW - supramolecular polymer

KW - tissue-engineered heart valve

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U2 - 10.1016/j.jacbts.2019.09.008

DO - 10.1016/j.jacbts.2019.09.008

M3 - Article

C2 - 32043018

VL - 5

SP - 15

EP - 31

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

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10.1016/j.jacbts.2019.09.008

published versionFinal published version, 5.43 MBLicence: CC BY-NC-ND

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