Differential leaflet remodeling of bone marrow cell pre-seeded versus nonseeded bioresorbable transcatheter pulmonary valve replacements

Emanuela Fioretta, Valentina Lintas, Anna Mallone, Sarah E. Motta, Lisa von Boehmer, Petra E. Dijkman, Nikola Cesarovic, Etem Caliskan, Hector Rodriguez Cetina Biefer, Miriam Lipiski, Mareike Sauer, Matilde Putti, Henk M. Janssen, Serge H.M. Söntjens, Anthal I.P.M. Smits, Carlijn V.C. Bouten, M.Y. Emmert (Corresponding author), Simon P. Hoerstrup (Corresponding author)

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Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.
Original languageEnglish
Pages (from-to)15-31
Number of pages17
JournalJACC: Basic to Translational Science
Volume5
Issue number1
Early online date11 Dec 2019
DOIs
Publication statusPublished - 1 Jan 2020

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Keywords

  • cardiovascular regenerative medicine
  • endogenous tissue regeneration
  • in situ tissue engineering
  • supramolecular polymer
  • tissue-engineered heart valve

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