Abstract
An aspect of intravascular medical procedures is the navigation to optimally
position the device, while avoiding tissue damage. If the conditions under which tissue damage occurs are known, this can be used to improve the device design. In vascular surgery, knowledge of a threshold force to prevent tissue damage helps to improve patient safety during the procedure. In this study, the threshold force at which a medical device punctures a vessel wall is measured. The measured force and device geometry are used to analyse local deformations and stress values using a finite element model. The tissue is described using the model developed and characterized in [1]. The purpose of this study is to find a relation between device geometry and the threshold force to avoid tissue damage for use in device design optimization.
The experimental set-up consists of a displacement-controlled holder for the medical device. A porcine artery is pre-strained to physiological conditions, with a soft substrate as support to mimic surrounding tissue. The force exerted by the device is measured. Fig. 1 shows a schematic of the set-up and the artery. The arterial tissue model developed in [1] is implemented into a finite element code through a user subroutine. It includes the observed loading/unloading hysteresis in arterial tissue using an internal damage variable.
The experimentally obtained force as a function of time (at constant speed) in Fig 2. is in qualitative agreement with results obtained in [2]. The threshold force at which the tissue is punctured by the medical device can be extracted. The local stress and internal damage levels at the threshold force for an unstressed vessel wall on a substrate can be analysed with a 2D plane strain FEM model (Fig. 2).
An experimental and numerical procedure have been developed to analyse device-induced tissue damage. As a next step, device tip geometries, substrates and angles of approach will be varied. Results will be used to optimize device design for minimal risk on tissue damage.
position the device, while avoiding tissue damage. If the conditions under which tissue damage occurs are known, this can be used to improve the device design. In vascular surgery, knowledge of a threshold force to prevent tissue damage helps to improve patient safety during the procedure. In this study, the threshold force at which a medical device punctures a vessel wall is measured. The measured force and device geometry are used to analyse local deformations and stress values using a finite element model. The tissue is described using the model developed and characterized in [1]. The purpose of this study is to find a relation between device geometry and the threshold force to avoid tissue damage for use in device design optimization.
The experimental set-up consists of a displacement-controlled holder for the medical device. A porcine artery is pre-strained to physiological conditions, with a soft substrate as support to mimic surrounding tissue. The force exerted by the device is measured. Fig. 1 shows a schematic of the set-up and the artery. The arterial tissue model developed in [1] is implemented into a finite element code through a user subroutine. It includes the observed loading/unloading hysteresis in arterial tissue using an internal damage variable.
The experimentally obtained force as a function of time (at constant speed) in Fig 2. is in qualitative agreement with results obtained in [2]. The threshold force at which the tissue is punctured by the medical device can be extracted. The local stress and internal damage levels at the threshold force for an unstressed vessel wall on a substrate can be analysed with a 2D plane strain FEM model (Fig. 2).
An experimental and numerical procedure have been developed to analyse device-induced tissue damage. As a next step, device tip geometries, substrates and angles of approach will be varied. Results will be used to optimize device design for minimal risk on tissue damage.
| Original language | English |
|---|---|
| Pages | 56-56 |
| Number of pages | 1 |
| Publication status | Published - 6 Sept 2022 |
| Event | Virtual Physiological Human Conference VPH 2022: Digital twins for personalized treatment development and clinical trials - Porto, Portugal Duration: 6 Sept 2022 → 9 Sept 2022 https://vph-conference.org/ |
Conference
| Conference | Virtual Physiological Human Conference VPH 2022 |
|---|---|
| Abbreviated title | VPH2022 |
| Country/Territory | Portugal |
| City | Porto |
| Period | 6/09/22 → 9/09/22 |
| Internet address |