Development of supramolecular metalloprotein mimics

M.C. Feiters, R.J.M. Klein Gebbink, A.P.H.J. Schenning, G.P.F. van Strijdonck, C.F. Martens, R.J.M. Nolte

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Abstract

Supramolecular mimics of metalloproteins, viz. cytochrome P-450 and ironsulfur proteins are described. The cytochrome P-450 mimic consists of a Mn porphyrin and a Rh complex which are incorporated within a vesicle membrane in water. This system catalyses the reductive activation of molecular oxygen in the epoxidation of alkenes at Mn, with reducing equivalents derived from the simultaneous Rh catalysed oxidation of formate to carbon dioxide. In the mimics for iron-sulfur proteins, iron-sulfur clusters are encapsulated in diphenylglycoluril and cyclotriveratrylene cavitands. The encapsulation by the cavitands modifies the electrochemical parameters, e.g. the redox potential, of the iron-sulfur clusters, in a way that has certain analogies to the effects of encapsulation by the protein in ferredoxins and high-potential iron-sulfur proteins.

LanguageEnglish
Pages2163-2170
Number of pages8
JournalPure and Applied Chemistry
Volume68
Issue number11
DOIs
StatePublished - 1 Jan 1996

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Metalloproteins
formic acid
Encapsulation
Sulfur
Cytochrome P-450 Enzyme System
Iron
Iron-Sulfur Proteins
Proteins
Ferredoxins
Epoxidation
Molecular oxygen
Porphyrins
Alkenes
Carbon Dioxide
Chemical activation
Membranes
Oxidation
Water
Olefins
Carbon dioxide

Cite this

Feiters, M. C., Klein Gebbink, R. J. M., Schenning, A. P. H. J., van Strijdonck, G. P. F., Martens, C. F., & Nolte, R. J. M. (1996). Development of supramolecular metalloprotein mimics. Pure and Applied Chemistry, 68(11), 2163-2170. DOI: 10.1351/pac199668112163
Feiters, M.C. ; Klein Gebbink, R.J.M. ; Schenning, A.P.H.J. ; van Strijdonck, G.P.F. ; Martens, C.F. ; Nolte, R.J.M./ Development of supramolecular metalloprotein mimics. In: Pure and Applied Chemistry. 1996 ; Vol. 68, No. 11. pp. 2163-2170
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Feiters, MC, Klein Gebbink, RJM, Schenning, APHJ, van Strijdonck, GPF, Martens, CF & Nolte, RJM 1996, 'Development of supramolecular metalloprotein mimics' Pure and Applied Chemistry, vol. 68, no. 11, pp. 2163-2170. DOI: 10.1351/pac199668112163

Development of supramolecular metalloprotein mimics. / Feiters, M.C.; Klein Gebbink, R.J.M.; Schenning, A.P.H.J.; van Strijdonck, G.P.F.; Martens, C.F.; Nolte, R.J.M.

In: Pure and Applied Chemistry, Vol. 68, No. 11, 01.01.1996, p. 2163-2170.

Research output: Contribution to journalArticleAcademicpeer-review

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Feiters MC, Klein Gebbink RJM, Schenning APHJ, van Strijdonck GPF, Martens CF, Nolte RJM. Development of supramolecular metalloprotein mimics. Pure and Applied Chemistry. 1996 Jan 1;68(11):2163-2170. Available from, DOI: 10.1351/pac199668112163