Development of morphologically discrete PEG-PDLLA nanotubes for precision nanomedicine

Annelies C. Wauters, Imke A.B. Pijpers, Alexander F. Mason, David S. Williams, Jurjen Tel, Loai K.E.A. Abdelmohsen (Corresponding author), Jan C.M. van Hest (Corresponding author)

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Abstract

Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the generation of well-defined nanotubes based on polymersomes as small as 250 and 100 nm, which can be successfully shape transformed. The quality of the resulting nanostructures was established by physical characterization using AF4-MALS and cryo-TEM. Moreover, we show the successful loading of such nanotubes with model payloads (proteins and drugs). These findings provide a promising platform for implementation in biomedical applications in which discrete structure and functionality are essential features.

LanguageEnglish
Pages177-183
JournalBiomacromolecules
Volume20
Issue number1
DOIs
StatePublished - 1 Jan 2019

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Medical nanotechnology
Nanotubes
Polyethylene glycols
Particle interactions
Nanostructures
Nanoparticles
Transmission electron microscopy
Proteins
Pharmaceutical Preparations

Cite this

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abstract = "Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the generation of well-defined nanotubes based on polymersomes as small as 250 and 100 nm, which can be successfully shape transformed. The quality of the resulting nanostructures was established by physical characterization using AF4-MALS and cryo-TEM. Moreover, we show the successful loading of such nanotubes with model payloads (proteins and drugs). These findings provide a promising platform for implementation in biomedical applications in which discrete structure and functionality are essential features.",
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AU - Pijpers,Imke A.B.

AU - Mason,Alexander F.

AU - Williams,David S.

AU - Tel,Jurjen

AU - Abdelmohsen,Loai K.E.A.

AU - van Hest,Jan C.M.

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