Development of methods for the determination of pKa values

J.C. Reijenga, A.J.F. van Hoof, A.H.M. van Loon, A.J.P. Teunissen

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The acid dissociation constant (pKa) is among the most frequently used physicochemical parameters, and its determination is of interest to a wide range of research fields. We present a brief introduction on the conceptual development of pKa as a physical parameter and its relationship to the concept of the pH of a solution. This is followed by a general summary of the historical development and current state of the techniques of pKa determination and an attempt to develop determination and an attempt to develop insight into future developments. Fourteen methods of determining the acid dissociation constant are placed in context and are critically evaluated to make a fair comparison and to determine their applications in modern chemistry. Additionally, we have studied these techniques in light of present trends in science and technology and attempt to determine how these trends might affect future developments in the field.

Original languageEnglish
Pages (from-to)53-71
Number of pages19
JournalAnalytical Chemistry Insights
Issue number1
Publication statusPublished - 2013


  • Dissociation constant
  • History
  • pH
  • PK
  • Review


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