Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

A. Mocroft; J.D. Lundgren; M. Ross; M. Law; P. Reiss; O. Kirk; C. Smith; D. Wentworth; J. Neuhaus; C.A. Fux; O. Moranne; P. Morlat; M.A. Johnson; L. Ryom

doi:10.1371/journal.pmed.1001809

Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

A. Mocroft
, J.D. Lundgren
, M. Ross
, M. Law
, P. Reiss
, O. Kirk
, C. Smith
, D. Wentworth
, J. Neuhaus
, C.A. Fux
, O. Moranne
, P. Morlat
, M.A. Johnson
, L. Ryom

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

117 Citations (Scopus)

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Abstract

Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.

Original language	English
Article number	e1001809
Journal	PLos Medicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.1371/journal.pmed.1001809
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Mocroft, A., Lundgren, J. D., Ross, M., Law, M., Reiss, P., Kirk, O., Smith, C., Wentworth, D., Neuhaus, J., Fux, C. A., Moranne, O., Morlat, P., Johnson, M. A., & Ryom, L. (2015). Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study. PLos Medicine, 12(3), Article e1001809. https://doi.org/10.1371/journal.pmed.1001809

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abstract = "Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.",

author = "A. Mocroft and J.D. Lundgren and M. Ross and M. Law and P. Reiss and O. Kirk and C. Smith and D. Wentworth and J. Neuhaus and C.A. Fux and O. Moranne and P. Morlat and M.A. Johnson and L. Ryom",

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Mocroft, A, Lundgren, JD, Ross, M, Law, M, Reiss, P, Kirk, O, Smith, C, Wentworth, D, Neuhaus, J, Fux, CA, Moranne, O, Morlat, P, Johnson, MA & Ryom, L 2015, 'Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study', PLos Medicine, vol. 12, no. 3, e1001809. https://doi.org/10.1371/journal.pmed.1001809

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T1 - Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

AU - Mocroft, A.

AU - Lundgren, J.D.

AU - Ross, M.

AU - Law, M.

AU - Reiss, P.

AU - Kirk, O.

AU - Smith, C.

AU - Wentworth, D.

AU - Neuhaus, J.

AU - Fux, C.A.

AU - Moranne, O.

AU - Morlat, P.

AU - Johnson, M.A.

AU - Ryom, L.

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N2 - Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.

AB - Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.

U2 - 10.1371/journal.pmed.1001809

DO - 10.1371/journal.pmed.1001809

M3 - Article

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SN - 1549-1277

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JO - PLos Medicine

JF - PLos Medicine

IS - 3

M1 - e1001809

ER -

Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

Abstract

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