Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study

A. Mocroft, J.D. Lundgren, M. Ross, M. Law, P. Reiss, O. Kirk, C. Smith, D. Wentworth, J. Neuhaus, C.A. Fux, O. Moranne, P. Morlat, M.A. Johnson, L. Ryom

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Abstract

Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice.
Original languageEnglish
Article numbere1001809
JournalPLos Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 2015

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