Development and evaluation of an interface for coupled capillary supercritical fluid chromatography/magnetic sector mass spectrometry : application to thermally unstable and high molecular mass compounds

M.A.A. Mertens, J.G.M. Janssen, C.A.M.G. Cramers, W.J.L. Genuit, G.J. Velzen, van, H Dirkzwager, H. Binsbergen, van

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

An interface for coupling supercritical fluid chromatography to a magnetic sector mass spectrometer was developed and evaluated. The interface is based on direct introduction of the mobile phase, carbon dioxide, into the ion-source of the mass spectrometer. The SFC-MS system was optimized with respect to the signal-to-noise ratio. Under optimized conditions, the estimated detection limit for n-pentadecane is approximately 30 ppm. Spectra obtained in the electron-impact ionization mode show a very good similarity with library spectra. The performance of the SFC-MS system was evaluated by the analysis of a number of test mixtures. A sample containing several low molecular mass, thermally unstable compounds, which could neither be analyzed by GC-MS nor by LC-MS, was analyzed. Also for the analysis of high molecular mass compounds, the coupled system showed a good performance.
Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJournal of High Resolution Chromatography
Volume19
Issue number1
DOIs
Publication statusPublished - 1996

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