Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction

Murat Isik; Ruslan Guliyev; Safacan Kolemen; Y. Altay; Berna Senturk; Turgay  Tekinay; Engin U.  Akkaya

doi:10.1021/ol501272z

Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction

Murat Isik
, Ruslan Guliyev
, Safacan Kolemen
, Y. Altay
, Berna Senturk
, Turgay Tekinay
, Engin U. Akkaya

Research output: Contribution to journal › Article › Academic › peer-review

106 Citations (Scopus)

Abstract

A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.

Original language	English
Pages (from-to)	3260-3263
Journal	Organic Letters
Volume	16
Issue number	12
DOIs	https://doi.org/10.1021/ol501272z
Publication status	Published - 2014
Externally published	Yes

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10.1021/ol501272z

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title = "Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction",

abstract = "A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.",

author = "Murat Isik and Ruslan Guliyev and Safacan Kolemen and Y. Altay and Berna Senturk and Turgay Tekinay and Akkaya, \{Engin U.\}",

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T1 - Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction

AU - Isik, Murat

AU - Guliyev, Ruslan

AU - Kolemen, Safacan

AU - Altay, Y.

AU - Senturk, Berna

AU - Tekinay, Turgay

AU - Akkaya, Engin U.

PY - 2014

Y1 - 2014

N2 - A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.

AB - A selective probe for glutathione was designed and synthesized. The design incorporates spatial and photophysical constraints for the maximal emission signal. Thus, pHs, as well as the intracellular thiol concentrations, determine the emission signal intensity through a tight control of charge-transfer and PeT processes. The probe works satisfactorily inside the human breast adenocarcinoma cells, highlighting GSH distribution in the cytosol.

U2 - 10.1021/ol501272z

DO - 10.1021/ol501272z

M3 - Article

SN - 1523-7060

VL - 16

SP - 3260

EP - 3263

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Designing an intracellular fluorescent probe for glutathione: two modulation sites for selective signal transduction

Abstract

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