Design of hydrated porphyrin-phospholipid bilayers with enhanced magnetic resonance contrast

S. Shao; T.N. Do; A. Razi; U. Chitgupi; J. Geng; R.J. Alsop; B.G. Dzikovski; M.C. Rheinstädter; J. Ortega; M. Karttunen; J.A. Spernyak; J.F. Lovell

doi:10.1002/smll.201602505

Design of hydrated porphyrin-phospholipid bilayers with enhanced magnetic resonance contrast

S. Shao, T.N. Do, A. Razi, U. Chitgupi, J. Geng, R.J. Alsop, B.G. Dzikovski, M.C. Rheinstädter, J. Ortega, M. Karttunen, J.A. Spernyak, J.F. Lovell

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo

Original language	English
Article number	1602505
Number of pages	6
Journal	Small : Nano Micro
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/smll.201602505
Publication status	Published - 4 Jan 2017

Keywords

bilayers
contrast agents
MD simulations
porphyrin-phospholipid
water permeation
Contrast Media/chemistry
Magnetic Resonance Spectroscopy
Liposomes/chemistry
Phospholipids/chemistry
Water/chemistry
Molecular Dynamics Simulation
Lipid Bilayers/chemistry
Porphyrins/chemistry

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10.1002/smll.201602505

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abstract = "Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo",

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AU - Do, T.N.

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AU - Geng, J.

AU - Alsop, R.J.

AU - Dzikovski, B.G.

AU - Rheinstädter, M.C.

AU - Ortega, J.

AU - Karttunen, M.

AU - Spernyak, J.A.

AU - Lovell, J.F.

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KW - water permeation

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KW - Phospholipids/chemistry

KW - Water/chemistry

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Design of hydrated porphyrin-phospholipid bilayers with enhanced magnetic resonance contrast

Abstract

Keywords

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