Design of hydrated porphyrin-phospholipid bilayers with enhanced magnetic resonance contrast

S. Shao, T.N. Do, A. Razi, U. Chitgupi, J. Geng, R.J. Alsop, B.G. Dzikovski, M.C. Rheinstädter, J. Ortega, M. Karttunen, J.A. Spernyak, J.F. Lovell

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo
Original languageEnglish
Article number1602505
Number of pages6
JournalSmall
Volume13
Issue number1
DOIs
Publication statusPublished - 4 Jan 2017

Keywords

  • bilayers
  • contrast agents
  • MD simulations
  • porphyrin-phospholipid
  • water permeation
  • Contrast Media/chemistry
  • Magnetic Resonance Spectroscopy
  • Liposomes/chemistry
  • Phospholipids/chemistry
  • Water/chemistry
  • Molecular Dynamics Simulation
  • Lipid Bilayers/chemistry
  • Porphyrins/chemistry

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