Design of electrospinning mesh devices

This paper describes the features of new membranes that can act as local biomedical devices owing to their peculiar shape in the form of mesh structure. These materials are designed to provide significant effects to reduce local inflammations and improve the tissue regeneration. Lamellar Hydrotalcite loaded with Diclofenac Sodium (HTLc-DIK) was homogenously dispersed inside a polymeric matrix of Poly-caprolactone (PCL) to manufacture membranes by electrospinning technique. The experimental procedure and the criteria employed have shown to be extremely effective at increasing potentiality and related applications. The employed technique has proved to be very useful to manufacture polymeric fibers with diameters in the range of nano-micro scale. In this work a dedicated collector based on a proprietary technology of IME Technologies and Eindhoven University of Technology (TU/e) was used. It allowed to obtain devices with a macro shape of a 3D-mesh. Atomic Force Microscopy (AFM) highlights a very interesting texture of the electrospun fibers. They show a lamellar morphology that is only slightly modified by the inclusion of the interclay embedded in the devices to control the drug release phenomena.