Design of electroporation process in irregularly shaped multicellular systems

Luciano Mescia (Corresponding author), Michele Alessandro Chiapperino, Pietro Bia, Claudio Maria Lamacchia, Johan Gielis, Diego Caratelli

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
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Electroporation technique is widely used in biotechnology and medicine for the transport of various molecules through the membranes of biological cells. Different mathematical models of electroporation have been proposed in the literature to study pore formation in plasma and nuclear membranes. These studies are mainly based on models using a single isolated cell with a canonical shape. In this work, a space–time (x,y,t) multiphysics model based on quasi-static Maxwell’s equations and nonlinear Smoluchowski’s equation has been developed to investigate the electroporation phenomenon induced by pulsed electric field in multicellular systems having irregularly shape. The dielectric dispersion of the cell compartments such as nuclear and plasmatic membranes, cytoplasm, nucleoplasm and external medium have been incorporated into the numerical algorithm, too. Moreover, the irregular cell shapes have been modeled by using the Gielis transformations.

Original languageEnglish
Article number37
Number of pages17
Issue number1
Publication statusPublished - 1 Jan 2019


  • Computational model
  • Dielectric dispersion
  • Nucleated biological cells
  • Pulsed electric field
  • Transmembrane voltage


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