Design and synthesis of a bimodal target-specific contrast agent for angiogenesis

A. Dirksen; S. Langereis; B.F.M. Waal, de; M.H.P. Genderen, van; E.W. Meijer; Q.G Lussanet, de; T.M. Hackeng

doi:10.1021/ol048084u

Design and synthesis of a bimodal target-specific contrast agent for angiogenesis

A. Dirksen, S. Langereis, B.F.M. Waal, de, M.H.P. Genderen, van, E.W. Meijer, Q.G Lussanet, de, T.M. Hackeng

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Abstract

A bimodal target-specific contrast agent based on a cyclic peptide contg. the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chem. ligation, and gives a straightforward approach for double labeling of peptides in general.

Original language	English
Pages (from-to)	4857-4860
Journal	Organic Letters
Volume	6
Issue number	26
DOIs	https://doi.org/10.1021/ol048084u
Publication status	Published - 2004

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abstract = "A bimodal target-specific contrast agent based on a cyclic peptide contg. the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chem. ligation, and gives a straightforward approach for double labeling of peptides in general.",

author = "A. Dirksen and S. Langereis and {Waal, de}, B.F.M. and {Genderen, van}, M.H.P. and E.W. Meijer and {Lussanet, de}, Q.G and T.M. Hackeng",

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T1 - Design and synthesis of a bimodal target-specific contrast agent for angiogenesis

AU - Dirksen, A.

AU - Langereis, S.

AU - Waal, de, B.F.M.

AU - Genderen, van, M.H.P.

AU - Meijer, E.W.

AU - Lussanet, de, Q.G

AU - Hackeng, T.M.

PY - 2004

Y1 - 2004

N2 - A bimodal target-specific contrast agent based on a cyclic peptide contg. the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chem. ligation, and gives a straightforward approach for double labeling of peptides in general.

AB - A bimodal target-specific contrast agent based on a cyclic peptide contg. the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chem. ligation, and gives a straightforward approach for double labeling of peptides in general.

U2 - 10.1021/ol048084u

DO - 10.1021/ol048084u

M3 - Article

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SN - 1523-7060

VL - 6

SP - 4857

EP - 4860

JO - Organic Letters

JF - Organic Letters

IS - 26

ER -

Design and synthesis of a bimodal target-specific contrast agent for angiogenesis

Abstract

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