Design and synthesis of a bimodal target-specific contrast agent for angiogenesis

A. Dirksen, S. Langereis, B.F.M. Waal, de, M.H.P. Genderen, van, E.W. Meijer, Q.G Lussanet, de, T.M. Hackeng

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)
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Abstract

A bimodal target-specific contrast agent based on a cyclic peptide contg. the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chem. ligation, and gives a straightforward approach for double labeling of peptides in general.
Original languageEnglish
Pages (from-to)4857-4860
JournalOrganic Letters
Volume6
Issue number26
DOIs
Publication statusPublished - 2004

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