Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study

Kelly Nijsten; Loïs M. van der Minnen; Caitlin Dean; Joke M.J. Bais; Carrie Ris-Stalpers; Rik van Eekelen; Henk A. Bremer; David P. van der Ham; Wieteke M. Heidema; Anjoke Huisjes; Gunilla Kleiverda; Simone M. Kuppens; Judith O.E.H. van Laar; Josje Langenveld; Flip van der Made; Dimitri Papatsonis; Marie José Pelinck; Paula J. Pernet; Leonie van Rheenen-Flach; Robbert J. Rijnders; Hubertina C.J. Scheepers; Tatjana Vogelvang; Ben W. Mol; Miranda Olff; Tessa J. Roseboom; Marjette H. Koot; Iris J. Grooten; Rebecca C. Painter

doi:10.1080/14767058.2022.2089550

Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study

Kelly Nijsten (Corresponding author)
, Loïs M. van der Minnen
, Caitlin Dean
, Joke M.J. Bais
, Carrie Ris-Stalpers
, Rik van Eekelen
, Henk A. Bremer
, David P. van der Ham
, Wieteke M. Heidema
, Anjoke Huisjes
, Gunilla Kleiverda
, Simone M. Kuppens
, Judith O.E.H. van Laar
, Josje Langenveld
, Flip van der Made
, Dimitri Papatsonis
, Marie José Pelinck
, Paula J. Pernet
, Leonie van Rheenen-Flach
, Robbert J. Rijnders

Hubertina C.J. Scheepers, Tatjana Vogelvang, Ben W. Mol, Miranda Olff, Tessa J. Roseboom, Marjette H. Koot, Iris J. Grooten, Rebecca C. Painter

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

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Abstract

Objective: To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) and its association with HG severity. Material and methods: This prospective cohort study consisted of a follow-up of 215 women admitted for HG, who were eligible to participate in a randomized controlled trial and either declined or agreed to be randomized between 2013 and 2016 in 19 hospitals in the Netherlands. Participants completed the Hospital Anxiety and Depression Scale (HADS) six weeks postpartum and during follow-up and the PTSD checklist for DSM-5 (PCL-5) during follow-up. An anxiety or depression score ≥8 is indicative of an anxiety or depression disorder and a PCL-5 ≥ 31 indicative of PTSD. Measures of HG severity were symptom severity (PUQE-24: Pregnancy Unique Quantification of Emesis), weight change, duration of admissions, readmissions, and admissions after the first trimester. Results: About 54/215 participants completed the HADS six weeks postpartum and 73/215 participants completed the follow-up questionnaire, on average 4.5 years later. Six weeks postpartum, 13 participants (24.1%) had an anxiety score ≥8 and 11 participants (20.4%) a depression score ≥8. During follow-up, 29 participants (39.7%) had an anxiety score ≥8, 20 participants (27.4%) a depression score ≥8, and 16 participants (21.9%) a PCL-5 ≥ 31. Multivariable logistic regression analysis showed that for every additional point of the mean PUQE-24 three weeks after inclusion, the likelihood of having an anxiety score ≥8 and PCL-5 ≥ 31 at follow-up increased with OR 1.41 (95% CI: 1.10;1.79) and OR 1.49 (95% CI: 1.06;2.10) respectively. Conclusion: Depression, anxiety, and PTSD symptoms are common years after HG occurred.

Original language	English
Pages (from-to)	10055-10063
Number of pages	9
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	35
Issue number	25
DOIs	https://doi.org/10.1080/14767058.2022.2089550
Publication status	Published - 2022

Bibliographical note

Funding Information:
Dr B.W. Mol reports grants from NHMRC outside the submitted work. Dr R.C. Painter reports grants from Amsterdam Reproduction and Development, during the conduct of the study, and she is the clinical and scientific advisor to the Dutch patient organization for Hyperemesis Gravidarum. She was also the chair of the organizing committee for the 3rd International Collaboration on Hyperemesis Gravidarum conference, Amsterdam, October 2019. Drs K. Nijsten and all other authors report no conflict of interests. ICMJE disclosure of interest forms are submitted as supporting information .

Funding

Dr B.W. Mol reports grants from NHMRC outside the submitted work. Dr R.C. Painter reports grants from Amsterdam Reproduction and Development, during the conduct of the study, and she is the clinical and scientific advisor to the Dutch patient organization for Hyperemesis Gravidarum. She was also the chair of the organizing committee for the 3rd International Collaboration on Hyperemesis Gravidarum conference, Amsterdam, October 2019. Drs K. Nijsten and all other authors report no conflict of interests. ICMJE disclosure of interest forms are submitted as supporting information .

Keywords

anxiety disorder
depression disorder
Hyperemesis gravidarum
postpartum depression
posttraumatic stress disorder
Prospective Studies
Anxiety/etiology
Humans
Stress Disorders, Post-Traumatic/epidemiology
Hyperemesis Gravidarum/complications
Pregnancy
Female
Depression/etiology

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Nijsten, K., van der Minnen, L. M., Dean, C., Bais, J. M. J., Ris-Stalpers, C., van Eekelen, R., Bremer, H. A., van der Ham, D. P., Heidema, W. M., Huisjes, A., Kleiverda, G., Kuppens, S. M., van Laar, J. O. E. H., Langenveld, J., van der Made, F., Papatsonis, D., Pelinck, M. J., Pernet, P. J., van Rheenen-Flach, L., ... Painter, R. C. (2022). Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study. Journal of Maternal-Fetal and Neonatal Medicine, 35(25), 10055-10063. https://doi.org/10.1080/14767058.2022.2089550

@article{03a6e14d277b4997a90164afa951c3fc,

title = "Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study",

abstract = "Objective: To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) and its association with HG severity. Material and methods: This prospective cohort study consisted of a follow-up of 215 women admitted for HG, who were eligible to participate in a randomized controlled trial and either declined or agreed to be randomized between 2013 and 2016 in 19 hospitals in the Netherlands. Participants completed the Hospital Anxiety and Depression Scale (HADS) six weeks postpartum and during follow-up and the PTSD checklist for DSM-5 (PCL-5) during follow-up. An anxiety or depression score ≥8 is indicative of an anxiety or depression disorder and a PCL-5 ≥ 31 indicative of PTSD. Measures of HG severity were symptom severity (PUQE-24: Pregnancy Unique Quantification of Emesis), weight change, duration of admissions, readmissions, and admissions after the first trimester. Results: About 54/215 participants completed the HADS six weeks postpartum and 73/215 participants completed the follow-up questionnaire, on average 4.5 years later. Six weeks postpartum, 13 participants (24.1\%) had an anxiety score ≥8 and 11 participants (20.4\%) a depression score ≥8. During follow-up, 29 participants (39.7\%) had an anxiety score ≥8, 20 participants (27.4\%) a depression score ≥8, and 16 participants (21.9\%) a PCL-5 ≥ 31. Multivariable logistic regression analysis showed that for every additional point of the mean PUQE-24 three weeks after inclusion, the likelihood of having an anxiety score ≥8 and PCL-5 ≥ 31 at follow-up increased with OR 1.41 (95\% CI: 1.10;1.79) and OR 1.49 (95\% CI: 1.06;2.10) respectively. Conclusion: Depression, anxiety, and PTSD symptoms are common years after HG occurred.",

keywords = "anxiety disorder, depression disorder, Hyperemesis gravidarum, postpartum depression, posttraumatic stress disorder, Prospective Studies, Anxiety/etiology, Humans, Stress Disorders, Post-Traumatic/epidemiology, Hyperemesis Gravidarum/complications, Pregnancy, Female, Depression/etiology",

author = "Kelly Nijsten and \{van der Minnen\}, \{Lo{\"i}s M.\} and Caitlin Dean and Bais, \{Joke M.J.\} and Carrie Ris-Stalpers and \{van Eekelen\}, Rik and Bremer, \{Henk A.\} and \{van der Ham\}, \{David P.\} and Heidema, \{Wieteke M.\} and Anjoke Huisjes and Gunilla Kleiverda and Kuppens, \{Simone M.\} and \{van Laar\}, \{Judith O.E.H.\} and Josje Langenveld and \{van der Made\}, Flip and Dimitri Papatsonis and Pelinck, \{Marie Jos{\'e}\} and Pernet, \{Paula J.\} and \{van Rheenen-Flach\}, Leonie and Rijnders, \{Robbert J.\} and Scheepers, \{Hubertina C.J.\} and Tatjana Vogelvang and Mol, \{Ben W.\} and Miranda Olff and Roseboom, \{Tessa J.\} and Koot, \{Marjette H.\} and Grooten, \{Iris J.\} and Painter, \{Rebecca C.\}",

note = "Funding Information: Dr B.W. Mol reports grants from NHMRC outside the submitted work. Dr R.C. Painter reports grants from Amsterdam Reproduction and Development, during the conduct of the study, and she is the clinical and scientific advisor to the Dutch patient organization for Hyperemesis Gravidarum. She was also the chair of the organizing committee for the 3rd International Collaboration on Hyperemesis Gravidarum conference, Amsterdam, October 2019. Drs K. Nijsten and all other authors report no conflict of interests. ICMJE disclosure of interest forms are submitted as supporting information . ",

year = "2022",

doi = "10.1080/14767058.2022.2089550",

language = "English",

volume = "35",

pages = "10055--10063",

journal = "Journal of Maternal-Fetal and Neonatal Medicine",

issn = "1476-7058",

publisher = "Taylor and Francis Ltd.",

number = "25",

}

Nijsten, K, van der Minnen, LM, Dean, C, Bais, JMJ, Ris-Stalpers, C, van Eekelen, R, Bremer, HA, van der Ham, DP, Heidema, WM, Huisjes, A, Kleiverda, G, Kuppens, SM, van Laar, JOEH, Langenveld, J, van der Made, F, Papatsonis, D, Pelinck, MJ, Pernet, PJ, van Rheenen-Flach, L, Rijnders, RJ, Scheepers, HCJ, Vogelvang, T, Mol, BW, Olff, M, Roseboom, TJ, Koot, MH, Grooten, IJ & Painter, RC 2022, 'Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study', Journal of Maternal-Fetal and Neonatal Medicine, vol. 35, no. 25, pp. 10055-10063. https://doi.org/10.1080/14767058.2022.2089550

Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study. / Nijsten, Kelly (Corresponding author); van der Minnen, Loïs M.; Dean, Caitlin et al.
In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 35, No. 25, 2022, p. 10055-10063.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum

T2 - a prospective cohort study

AU - Nijsten, Kelly

AU - van der Minnen, Loïs M.

AU - Dean, Caitlin

AU - Bais, Joke M.J.

AU - Ris-Stalpers, Carrie

AU - van Eekelen, Rik

AU - Bremer, Henk A.

AU - van der Ham, David P.

AU - Heidema, Wieteke M.

AU - Huisjes, Anjoke

AU - Kleiverda, Gunilla

AU - Kuppens, Simone M.

AU - van Laar, Judith O.E.H.

AU - Langenveld, Josje

AU - van der Made, Flip

AU - Papatsonis, Dimitri

AU - Pelinck, Marie José

AU - Pernet, Paula J.

AU - van Rheenen-Flach, Leonie

AU - Rijnders, Robbert J.

AU - Scheepers, Hubertina C.J.

AU - Vogelvang, Tatjana

AU - Mol, Ben W.

AU - Olff, Miranda

AU - Roseboom, Tessa J.

AU - Koot, Marjette H.

AU - Grooten, Iris J.

AU - Painter, Rebecca C.

N1 - Funding Information: Dr B.W. Mol reports grants from NHMRC outside the submitted work. Dr R.C. Painter reports grants from Amsterdam Reproduction and Development, during the conduct of the study, and she is the clinical and scientific advisor to the Dutch patient organization for Hyperemesis Gravidarum. She was also the chair of the organizing committee for the 3rd International Collaboration on Hyperemesis Gravidarum conference, Amsterdam, October 2019. Drs K. Nijsten and all other authors report no conflict of interests. ICMJE disclosure of interest forms are submitted as supporting information .

PY - 2022

Y1 - 2022

N2 - Objective: To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) and its association with HG severity. Material and methods: This prospective cohort study consisted of a follow-up of 215 women admitted for HG, who were eligible to participate in a randomized controlled trial and either declined or agreed to be randomized between 2013 and 2016 in 19 hospitals in the Netherlands. Participants completed the Hospital Anxiety and Depression Scale (HADS) six weeks postpartum and during follow-up and the PTSD checklist for DSM-5 (PCL-5) during follow-up. An anxiety or depression score ≥8 is indicative of an anxiety or depression disorder and a PCL-5 ≥ 31 indicative of PTSD. Measures of HG severity were symptom severity (PUQE-24: Pregnancy Unique Quantification of Emesis), weight change, duration of admissions, readmissions, and admissions after the first trimester. Results: About 54/215 participants completed the HADS six weeks postpartum and 73/215 participants completed the follow-up questionnaire, on average 4.5 years later. Six weeks postpartum, 13 participants (24.1%) had an anxiety score ≥8 and 11 participants (20.4%) a depression score ≥8. During follow-up, 29 participants (39.7%) had an anxiety score ≥8, 20 participants (27.4%) a depression score ≥8, and 16 participants (21.9%) a PCL-5 ≥ 31. Multivariable logistic regression analysis showed that for every additional point of the mean PUQE-24 three weeks after inclusion, the likelihood of having an anxiety score ≥8 and PCL-5 ≥ 31 at follow-up increased with OR 1.41 (95% CI: 1.10;1.79) and OR 1.49 (95% CI: 1.06;2.10) respectively. Conclusion: Depression, anxiety, and PTSD symptoms are common years after HG occurred.

AB - Objective: To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) and its association with HG severity. Material and methods: This prospective cohort study consisted of a follow-up of 215 women admitted for HG, who were eligible to participate in a randomized controlled trial and either declined or agreed to be randomized between 2013 and 2016 in 19 hospitals in the Netherlands. Participants completed the Hospital Anxiety and Depression Scale (HADS) six weeks postpartum and during follow-up and the PTSD checklist for DSM-5 (PCL-5) during follow-up. An anxiety or depression score ≥8 is indicative of an anxiety or depression disorder and a PCL-5 ≥ 31 indicative of PTSD. Measures of HG severity were symptom severity (PUQE-24: Pregnancy Unique Quantification of Emesis), weight change, duration of admissions, readmissions, and admissions after the first trimester. Results: About 54/215 participants completed the HADS six weeks postpartum and 73/215 participants completed the follow-up questionnaire, on average 4.5 years later. Six weeks postpartum, 13 participants (24.1%) had an anxiety score ≥8 and 11 participants (20.4%) a depression score ≥8. During follow-up, 29 participants (39.7%) had an anxiety score ≥8, 20 participants (27.4%) a depression score ≥8, and 16 participants (21.9%) a PCL-5 ≥ 31. Multivariable logistic regression analysis showed that for every additional point of the mean PUQE-24 three weeks after inclusion, the likelihood of having an anxiety score ≥8 and PCL-5 ≥ 31 at follow-up increased with OR 1.41 (95% CI: 1.10;1.79) and OR 1.49 (95% CI: 1.06;2.10) respectively. Conclusion: Depression, anxiety, and PTSD symptoms are common years after HG occurred.

KW - anxiety disorder

KW - depression disorder

KW - Hyperemesis gravidarum

KW - postpartum depression

KW - posttraumatic stress disorder

KW - Prospective Studies

KW - Anxiety/etiology

KW - Humans

KW - Stress Disorders, Post-Traumatic/epidemiology

KW - Hyperemesis Gravidarum/complications

KW - Pregnancy

KW - Female

KW - Depression/etiology

UR - https://www.scopus.com/pages/publications/85132753101

U2 - 10.1080/14767058.2022.2089550

DO - 10.1080/14767058.2022.2089550

M3 - Article

C2 - 35726837

AN - SCOPUS:85132753101

SN - 1476-7058

VL - 35

SP - 10055

EP - 10063

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 25

ER -

Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study

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