Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile

K. T. Al-Jamal, A. Nunes, L. Methven, H. Ali-Boucetta, Li Shouping, F. Toma, M.A. Herrero, W.T. Al-Jamal, H.M.M. Eikelder, ten, J. Foster, S. Mather, M. Prato, M. Bianco, K. Kostarelos

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Abstract

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.
Original languageEnglish
Pages (from-to)6389-6393
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number26
DOIs
Publication statusPublished - 2012

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Carbon Nanotubes
Carbon nanotubes
Tissue
Single photon emission computed tomography

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Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Shouping, L., Toma, F., ... Kostarelos, K. (2012). Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile. Angewandte Chemie - International Edition, 51(26), 6389-6393. https://doi.org/10.1002/anie.201201991
Al-Jamal, K. T. ; Nunes, A. ; Methven, L. ; Ali-Boucetta, H. ; Shouping, Li ; Toma, F. ; Herrero, M.A. ; Al-Jamal, W.T. ; Eikelder, ten, H.M.M. ; Foster, J. ; Mather, S. ; Prato, M. ; Bianco, M. ; Kostarelos, K. / Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 26. pp. 6389-6393.
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abstract = "Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.",
author = "Al-Jamal, {K. T.} and A. Nunes and L. Methven and H. Ali-Boucetta and Li Shouping and F. Toma and M.A. Herrero and W.T. Al-Jamal and {Eikelder, ten}, H.M.M. and J. Foster and S. Mather and M. Prato and M. Bianco and K. Kostarelos",
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Al-Jamal, KT, Nunes, A, Methven, L, Ali-Boucetta, H, Shouping, L, Toma, F, Herrero, MA, Al-Jamal, WT, Eikelder, ten, HMM, Foster, J, Mather, S, Prato, M, Bianco, M & Kostarelos, K 2012, 'Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile', Angewandte Chemie - International Edition, vol. 51, no. 26, pp. 6389-6393. https://doi.org/10.1002/anie.201201991

Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile. / Al-Jamal, K. T.; Nunes, A.; Methven, L.; Ali-Boucetta, H.; Shouping, Li; Toma, F.; Herrero, M.A.; Al-Jamal, W.T.; Eikelder, ten, H.M.M.; Foster, J.; Mather, S.; Prato, M.; Bianco, M.; Kostarelos, K.

In: Angewandte Chemie - International Edition, Vol. 51, No. 26, 2012, p. 6389-6393.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Degree of chemical functionalization of carbon nanotubes determine tissue distribution and excretion profile

AU - Al-Jamal, K. T.

AU - Nunes, A.

AU - Methven, L.

AU - Ali-Boucetta, H.

AU - Shouping, Li

AU - Toma, F.

AU - Herrero, M.A.

AU - Al-Jamal, W.T.

AU - Eikelder, ten, H.M.M.

AU - Foster, J.

AU - Mather, S.

AU - Prato, M.

AU - Bianco, M.

AU - Kostarelos, K.

PY - 2012

Y1 - 2012

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AB - Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

U2 - 10.1002/anie.201201991

DO - 10.1002/anie.201201991

M3 - Article

C2 - 22623333

VL - 51

SP - 6389

EP - 6393

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 0570-0833

IS - 26

ER -