Today most flowers physically pass through the Dutch auction houses on their fixed routes from growers located all over the world to European customers. Physical presence is necessary to allow for inspection, quality control and break-bulk activities. Several developments, such as increased internationalization and virtualization, stimulate the sector to develop an efficient European hub distribution network, in which cut flowers, plants and other products are delivered to detail, retail and e-tail (i.e. webshop) customers using different logistics concepts. The DaVinc3i project has had the objective to strengthen the international leading competitive position of the Dutch horticulture sector in a global, virtualized trade network by researching the opportunities for new logistics coordination, consolidation and collaboration concepts in extended international trade park networks. In the last years over 30 case studies with business partners have been conducted within the DaVinc3i project. In this chapter we highlight the main research advances and lessons learned when moving towards collaborative responsive logistics network designs for perishables, illustrated with five case studies.