Cytolytic toxins as triggers of plant immune response

Isabell Küfner; Christian Ottmann; Claudia Oecking; Thorsten Nürnberger

doi:10.1073/pnas.0902362

Cytolytic toxins as triggers of plant immune response

Isabell Küfner, Christian Ottmann, Claudia Oecking, Thorsten Nürnberger

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Abstract

NEP1-like proteins (NLPs) are secreted proteins from fungi, oomycetes and bacteria, triggering immune responses and cell death in dicotyledonous plants. It has been unclear for a long time, whether NLPs are toxins or triggers of plant immunity. In a recent study we report that NLPs are toxins that exert cytolytic activity on dicotyledonous plants. Mutational analysis revealed a causal link between membrane damaging, cell death inducing and virulence promoting properties of NLPs. Interestingly, also induction of immune responses by NLPs required the same protein fold, providing evidence for damage-induced immunity in plants. Structural similarity to pore forming toxins from marine invertebrates allows the proposal of a model for the mode of NLP interaction with the host's membrane.

Original language	English
Pages (from-to)	977-979
Number of pages	3
Journal	Plant Signaling & Behavior
Volume	4
Issue number	10
DOIs	https://doi.org/10.1073/pnas.0902362
Publication status	Published - Oct 2009
Externally published	Yes

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title = "Cytolytic toxins as triggers of plant immune response",

abstract = "NEP1-like proteins (NLPs) are secreted proteins from fungi, oomycetes and bacteria, triggering immune responses and cell death in dicotyledonous plants. It has been unclear for a long time, whether NLPs are toxins or triggers of plant immunity. In a recent study we report that NLPs are toxins that exert cytolytic activity on dicotyledonous plants. Mutational analysis revealed a causal link between membrane damaging, cell death inducing and virulence promoting properties of NLPs. Interestingly, also induction of immune responses by NLPs required the same protein fold, providing evidence for damage-induced immunity in plants. Structural similarity to pore forming toxins from marine invertebrates allows the proposal of a model for the mode of NLP interaction with the host's membrane.",

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AU - Küfner, Isabell

AU - Ottmann, Christian

AU - Oecking, Claudia

AU - Nürnberger, Thorsten

PY - 2009/10

Y1 - 2009/10

N2 - NEP1-like proteins (NLPs) are secreted proteins from fungi, oomycetes and bacteria, triggering immune responses and cell death in dicotyledonous plants. It has been unclear for a long time, whether NLPs are toxins or triggers of plant immunity. In a recent study we report that NLPs are toxins that exert cytolytic activity on dicotyledonous plants. Mutational analysis revealed a causal link between membrane damaging, cell death inducing and virulence promoting properties of NLPs. Interestingly, also induction of immune responses by NLPs required the same protein fold, providing evidence for damage-induced immunity in plants. Structural similarity to pore forming toxins from marine invertebrates allows the proposal of a model for the mode of NLP interaction with the host's membrane.

AB - NEP1-like proteins (NLPs) are secreted proteins from fungi, oomycetes and bacteria, triggering immune responses and cell death in dicotyledonous plants. It has been unclear for a long time, whether NLPs are toxins or triggers of plant immunity. In a recent study we report that NLPs are toxins that exert cytolytic activity on dicotyledonous plants. Mutational analysis revealed a causal link between membrane damaging, cell death inducing and virulence promoting properties of NLPs. Interestingly, also induction of immune responses by NLPs required the same protein fold, providing evidence for damage-induced immunity in plants. Structural similarity to pore forming toxins from marine invertebrates allows the proposal of a model for the mode of NLP interaction with the host's membrane.

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DO - 10.1073/pnas.0902362

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JO - Plant Signaling & Behavior

JF - Plant Signaling & Behavior

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Cytolytic toxins as triggers of plant immune response

Abstract

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