Current advances in the fabrication of microneedles for transdermal delivery

S. Indermun, R. Luttge, Y.E. Choonara, Pradeep Kumar, L.C. Toit, Du, G. Modi, V. Pillay

Research output: Contribution to journalArticleAcademicpeer-review

131 Citations (Scopus)

Abstract

The transdermal route is an excellent site for drug delivery due to the avoidance of gastric degradation and hepatic metabolism, in addition to easy accessibility. Although offering numerous attractive advantages, many available transdermal systems are not able to deliver drugs and other compounds as desired. The use of hypodermic needles, associated with phobia, pain and accidental needle-sticks has been used to overcome the delivery limitation of macromolecular compounds. The means to overcome the disadvantages of hypodermic needles has led to the development of microneedles for transdermal delivery. However, since the initial stages of microneedle fabrication, recent research has been conducted integrating various fabrication techniques for generating sophisticated microneedle devices for transdermal delivery including progress on their commercialization. A concerted effort has been made within this review to highlight the current advances of microneedles, and to provide an update of pharmaceutical research in the field of microneedle-assisted transdermal drug delivery systems. © 2014 Elsevier B.V.
LanguageEnglish
Pages130-138
JournalJournal of Controlled Release
Volume185
DOIs
StatePublished - 2014

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Needles
Needlestick Injuries
Macromolecular Substances
Phobic Disorders
Drug Delivery Systems
Pharmaceutical Preparations
Stomach
Pain
Equipment and Supplies
Liver
Research
Pharmaceutical Research

Cite this

Indermun, S., Luttge, R., Choonara, Y. E., Kumar, P., Toit, Du, L. C., Modi, G., & Pillay, V. (2014). Current advances in the fabrication of microneedles for transdermal delivery. Journal of Controlled Release, 185, 130-138. DOI: 10.1016/j.jconrel.2014.04.052
Indermun, S. ; Luttge, R. ; Choonara, Y.E. ; Kumar, Pradeep ; Toit, Du, L.C. ; Modi, G. ; Pillay, V./ Current advances in the fabrication of microneedles for transdermal delivery. In: Journal of Controlled Release. 2014 ; Vol. 185. pp. 130-138
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Indermun, S, Luttge, R, Choonara, YE, Kumar, P, Toit, Du, LC, Modi, G & Pillay, V 2014, 'Current advances in the fabrication of microneedles for transdermal delivery' Journal of Controlled Release, vol. 185, pp. 130-138. DOI: 10.1016/j.jconrel.2014.04.052

Current advances in the fabrication of microneedles for transdermal delivery. / Indermun, S.; Luttge, R.; Choonara, Y.E.; Kumar, Pradeep; Toit, Du, L.C.; Modi, G.; Pillay, V.

In: Journal of Controlled Release, Vol. 185, 2014, p. 130-138.

Research output: Contribution to journalArticleAcademicpeer-review

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Indermun S, Luttge R, Choonara YE, Kumar P, Toit, Du LC, Modi G et al. Current advances in the fabrication of microneedles for transdermal delivery. Journal of Controlled Release. 2014;185:130-138. Available from, DOI: 10.1016/j.jconrel.2014.04.052