Cryptogenic localization-related epilepsy with childhood onset: The problem of definition and prognosis

R.P. Reijs, S.G.M. van Mil, M.H.J.A. van Hall, J.B.A.M. Arends, J.W. Weber, W.O. Renier, A.P. Aldenkamp

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


BACKGROUND: Up to one-third of children with epilepsy are diagnosed with cryptogenic localization-related epilepsy (CLRE). CLRE is a large nonspecific category within the ILAE classification. For this population no unequivocal prognosis exists.

METHODS: Twenty-five articles describing aspects of CLRE were included in this review.

RESULTS: As a result of the progress in epilepsy research, as well as more advanced investigation in individual cases, the population with CLRE constantly changes. Also, disagreement on interpretation of the classification has resulted in striking differences between the populations described. High remission rates are reported, but relapse occurs frequently, leaving the long-term prognosis unforeseeable. This is reflected in academic and psychosocial prognosis, which is described to be problematic in CLRE specifically. Possible prognostic factors of CLRE in children have been identified: age at onset, seizure semiology, seizure frequency, intractability, interictal epileptiform activity on EEG, and premorbid IQ. These factors are explored to define subgroups within the CLRE population.

DISCUSSION: Prospective studies on well-defined CLRE cohorts are needed to identify factors that distinguish various prognostic subgroups. Specific attention should be focused on course of the epilepsy, scholastic achievement, and psychosocial outcome.

Original languageEnglish
Pages (from-to)693-702
Number of pages10
JournalEpilepsy and Behavior
Issue number4
Publication statusPublished - Jun 2006
Externally publishedYes


  • Child
  • Child Behavior Disorders
  • Cognition Disorders
  • Electroencephalography
  • Epilepsies, Partial
  • Humans
  • Prognosis


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