Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T

Michael J. van Rijssel (Corresponding author), Josien P.W. Pluim, Hui-Shan M Chan, Lieke van den Wildenberg, Alexander M.Th. Schmitz, Peter R. Luijten, Kenneth G.A. Gilhuijs, Dennis W.J. Klomp

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: Inhomogeneous excitation at ultrahigh field strengths (7T and above) compromises the reliability of quantified dynamic contrast-enhanced breast MRI. This can hamper the introduction of ultrahigh field MRI into the clinic. Compensation for this non-uniformity effect can consist of both hardware improvements and post-acquisition corrections. This paper investigated the correctable radiofrequency transmit ( B 1 + ) range post-acquisition in both simulations and patient data for 7T MRI.

METHODS: Simulations were conducted to determine the minimum B 1 + level at which corrections were still beneficial because of noise amplification. Two correction strategies leading to differences in noise amplification were tested. The effect of the corrections on a 7T patient data set (N = 38) with a wide range of B 1 + levels was investigated in terms of time-intensity curve types as well as washin, washout and peak enhancement values.

RESULTS: In simulations assuming a common amount of T1 saturation, the lowest B 1 + level at which the SNR of the corrected images was at least that of the original precontrast image was 43% of the nominal angle. After correction, time-intensity curve types changed in 24% of included patients, and the distribution of curve types corresponded better to the distribution found in literature. Additionally, the overlap between the distributions of washin, washout, and peak enhancement values for grade 1 and grade 2 tumors was slightly reduced.

CONCLUSION: Although the correctable range varies with the amount of T1 saturation, post-acquisition correction for inhomogeneous excitation was feasible down to B 1 + levels of 43% of the nominal angle in vivo.

Original languageEnglish
JournalMagnetic Resonance in Medicine
DOIs
Publication statusE-pub ahead of print - 27 Dec 2019

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Noise
Breast
Patient Simulation
Neoplasms
Datasets

Bibliographical note

© 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

Cite this

van Rijssel, Michael J. ; Pluim, Josien P.W. ; Chan, Hui-Shan M ; van den Wildenberg, Lieke ; Schmitz, Alexander M.Th. ; Luijten, Peter R. ; Gilhuijs, Kenneth G.A. ; Klomp, Dennis W.J. / Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T. In: Magnetic Resonance in Medicine. 2019.
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title = "Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T",
abstract = "PURPOSE: Inhomogeneous excitation at ultrahigh field strengths (7T and above) compromises the reliability of quantified dynamic contrast-enhanced breast MRI. This can hamper the introduction of ultrahigh field MRI into the clinic. Compensation for this non-uniformity effect can consist of both hardware improvements and post-acquisition corrections. This paper investigated the correctable radiofrequency transmit ( B 1 + ) range post-acquisition in both simulations and patient data for 7T MRI.METHODS: Simulations were conducted to determine the minimum B 1 + level at which corrections were still beneficial because of noise amplification. Two correction strategies leading to differences in noise amplification were tested. The effect of the corrections on a 7T patient data set (N = 38) with a wide range of B 1 + levels was investigated in terms of time-intensity curve types as well as washin, washout and peak enhancement values.RESULTS: In simulations assuming a common amount of T1 saturation, the lowest B 1 + level at which the SNR of the corrected images was at least that of the original precontrast image was 43{\%} of the nominal angle. After correction, time-intensity curve types changed in 24{\%} of included patients, and the distribution of curve types corresponded better to the distribution found in literature. Additionally, the overlap between the distributions of washin, washout, and peak enhancement values for grade 1 and grade 2 tumors was slightly reduced.CONCLUSION: Although the correctable range varies with the amount of T1 saturation, post-acquisition correction for inhomogeneous excitation was feasible down to B 1 + levels of 43{\%} of the nominal angle in vivo.",
author = "{van Rijssel}, {Michael J.} and Pluim, {Josien P.W.} and Chan, {Hui-Shan M} and {van den Wildenberg}, Lieke and Schmitz, {Alexander M.Th.} and Luijten, {Peter R.} and Gilhuijs, {Kenneth G.A.} and Klomp, {Dennis W.J.}",
note = "{\circledC} 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.",
year = "2019",
month = "12",
day = "27",
doi = "10.1002/mrm.28147",
language = "English",
journal = "Magnetic Resonance in Medicine",
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Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T. / van Rijssel, Michael J. (Corresponding author); Pluim, Josien P.W.; Chan, Hui-Shan M; van den Wildenberg, Lieke; Schmitz, Alexander M.Th.; Luijten, Peter R.; Gilhuijs, Kenneth G.A.; Klomp, Dennis W.J.

In: Magnetic Resonance in Medicine, 27.12.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T

AU - van Rijssel, Michael J.

AU - Pluim, Josien P.W.

AU - Chan, Hui-Shan M

AU - van den Wildenberg, Lieke

AU - Schmitz, Alexander M.Th.

AU - Luijten, Peter R.

AU - Gilhuijs, Kenneth G.A.

AU - Klomp, Dennis W.J.

N1 - © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

PY - 2019/12/27

Y1 - 2019/12/27

N2 - PURPOSE: Inhomogeneous excitation at ultrahigh field strengths (7T and above) compromises the reliability of quantified dynamic contrast-enhanced breast MRI. This can hamper the introduction of ultrahigh field MRI into the clinic. Compensation for this non-uniformity effect can consist of both hardware improvements and post-acquisition corrections. This paper investigated the correctable radiofrequency transmit ( B 1 + ) range post-acquisition in both simulations and patient data for 7T MRI.METHODS: Simulations were conducted to determine the minimum B 1 + level at which corrections were still beneficial because of noise amplification. Two correction strategies leading to differences in noise amplification were tested. The effect of the corrections on a 7T patient data set (N = 38) with a wide range of B 1 + levels was investigated in terms of time-intensity curve types as well as washin, washout and peak enhancement values.RESULTS: In simulations assuming a common amount of T1 saturation, the lowest B 1 + level at which the SNR of the corrected images was at least that of the original precontrast image was 43% of the nominal angle. After correction, time-intensity curve types changed in 24% of included patients, and the distribution of curve types corresponded better to the distribution found in literature. Additionally, the overlap between the distributions of washin, washout, and peak enhancement values for grade 1 and grade 2 tumors was slightly reduced.CONCLUSION: Although the correctable range varies with the amount of T1 saturation, post-acquisition correction for inhomogeneous excitation was feasible down to B 1 + levels of 43% of the nominal angle in vivo.

AB - PURPOSE: Inhomogeneous excitation at ultrahigh field strengths (7T and above) compromises the reliability of quantified dynamic contrast-enhanced breast MRI. This can hamper the introduction of ultrahigh field MRI into the clinic. Compensation for this non-uniformity effect can consist of both hardware improvements and post-acquisition corrections. This paper investigated the correctable radiofrequency transmit ( B 1 + ) range post-acquisition in both simulations and patient data for 7T MRI.METHODS: Simulations were conducted to determine the minimum B 1 + level at which corrections were still beneficial because of noise amplification. Two correction strategies leading to differences in noise amplification were tested. The effect of the corrections on a 7T patient data set (N = 38) with a wide range of B 1 + levels was investigated in terms of time-intensity curve types as well as washin, washout and peak enhancement values.RESULTS: In simulations assuming a common amount of T1 saturation, the lowest B 1 + level at which the SNR of the corrected images was at least that of the original precontrast image was 43% of the nominal angle. After correction, time-intensity curve types changed in 24% of included patients, and the distribution of curve types corresponded better to the distribution found in literature. Additionally, the overlap between the distributions of washin, washout, and peak enhancement values for grade 1 and grade 2 tumors was slightly reduced.CONCLUSION: Although the correctable range varies with the amount of T1 saturation, post-acquisition correction for inhomogeneous excitation was feasible down to B 1 + levels of 43% of the nominal angle in vivo.

U2 - 10.1002/mrm.28147

DO - 10.1002/mrm.28147

M3 - Article

C2 - 31880346

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -