Core-shell capsules based on supramolecular hydrogels show shell-related erosion and release due to confinement

M. Guo, X. Cao, E.W. Meijer, P.Y.W. Dankers

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2 Downloads (Pure)

Abstract

Hydrogel-containing core-shell capsules are useful as drug delivery vehicles for many biomedical applications, especially when release of incorporated guests can be controlled. Here, we developed a one-step organic solvent-free method to prepare such core-shell capsules using a synthetic and a natural supramolecular hydrogel, for the core and shell, respectively. A solution containing ureido-pyrimidinone modified poly(ethylene glycol) hydrogelators and calcium chloride was drop-wise added to an alginate solution, yielding core-shell structures. It was found that the outer shell provides a confined space for the inner supramolecular hydrogel and therefore prevents swelling of the core. This consequently slows down both erosion of the less stable core, and release of dextran guests.
Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalMacromolecular Bioscience
Volume13
Issue number1
DOIs
Publication statusPublished - 2013

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