Abstract
The self-assembly of two bis-2-ureido-4[1H]-pyrimidinones by eight intermol. hydrogen bonds results in extremely stable dimers. These dimers exist both in soln. and in the solid state as two different isomers. By single-crystal X-ray analyses the structures of both the syn-isomer and the anti-isomer have been detd. In addn., with ROESY expts. the structure of a third isomer is revealed. By a combination of NMR techniques the mutual rate of exchange has been detd. Interestingly, these values are significantly lower than the comparable processes of a single 2-ureido-4[1H]-pyrimidinone. These expts. allowed us to det. the cooperativity in conformational behavior and tautomerization of stable dimers
Original language | English |
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Pages (from-to) | 9001-9007 |
Number of pages | 7 |
Journal | Journal of the American Chemical Society |
Volume | 121 |
Issue number | 39 |
DOIs | |
Publication status | Published - 1999 |