Convective-dispersion modeling in 3D contrast-ultrasound imaging for the localization of prostate cancer

R.R. Wildeboer, R.J.G. van Sloun, S.G. Schalk, C.K. Mannaerts, J.C. van der Linden, P. Huang, H. Wijkstra, M. Mischi

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
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Abstract

Despite being the solid tumor with the highest incidence in western men, prostate cancer (PCa) still lacks reliable imaging solutions that can overcome the need for systematic biopsies. Dynamic contrast-enhanced ultrasound imaging (DCE-US) allows us to quantitatively characterize the vascular bed in the prostate, due to its ability to visualize an intravenously administered bolus of contrast agents. Previous research has demonstrated that DCE-US parameters related to the vascular architecture are useful markers for the localization of PCa lesions. In this paper, we propose a novel method to assess the convective dispersion (D) and velocity (v) of the contrast bolus spreading through the prostate from three-dimensional (3D) DCE-US recordings. By assuming that D and v are locally constant, we solve the convective-dispersion equation by minimizing the corresponding regularized least-squares problem. 3D multiparametric maps of D and v were compared with 3D histopathology retrieved from the radical prostatectomy specimens of six patients. With a pixel-wise area under the receiver operating characteristic curve of 0.72 and 0.80, respectively, the method shows diagnostic value for the localization of PCa.

Original languageEnglish
Article number8371214
Pages (from-to)2593-2602
Number of pages10
JournalIEEE Transactions on Medical Imaging
Volume37
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • 3D
  • Convection
  • Dispersion
  • Dynamic Contrast-Enhanced Ultrasound
  • Prostate Cancer
  • convection
  • dynamic contrast-enhanced ultrasound
  • dispersion
  • Prostate cancer
  • Imaging, Three-Dimensional/methods
  • Humans
  • Ultrasonography/methods
  • Male
  • Prostatic Neoplasms/diagnostic imaging
  • Contrast Media
  • Computer Simulation
  • Video Recording

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