TY - JOUR
T1 - Controlling the spatial distribution of solubilized compounds within copolymer micelles
AU - Ianiro, Alessandro
AU - González García, Álvaro
AU - Wijker, Stefan
AU - Patterson, Joseph P.
AU - Esteves, A. Catarina C.
AU - Tuinier, Remco
PY - 2019/4/2
Y1 - 2019/4/2
N2 - The solubilization of lyophobic compounds in block copolymer micelles has been extensively investigated but remains only partially understood. There is a need to understand the fundamental parameters that determine the spatial distribution of the solubilized compounds within the micelles. Controlling this feature is a key aspect in the design of drug delivery systems with tailored release properties. Using Scheutjens-Fleer self-consistent field (SF-SCF) computations, we found that solubilization is regulated by a complex interplay between enthalpic and entropic contributions and that the spatial distribution can be controlled by the concentration and solubility of the guest compound in the dispersion medium. Upon solubilization, a characteristic change in size and mass of the micelles is predicted. This can be used as a fingerprint to indirectly assess the spatial distribution. Based on these findings, we developed two experimental protocols to control and assess the spatial distribution of lyophobic compounds within block copolymer micelles.
AB - The solubilization of lyophobic compounds in block copolymer micelles has been extensively investigated but remains only partially understood. There is a need to understand the fundamental parameters that determine the spatial distribution of the solubilized compounds within the micelles. Controlling this feature is a key aspect in the design of drug delivery systems with tailored release properties. Using Scheutjens-Fleer self-consistent field (SF-SCF) computations, we found that solubilization is regulated by a complex interplay between enthalpic and entropic contributions and that the spatial distribution can be controlled by the concentration and solubility of the guest compound in the dispersion medium. Upon solubilization, a characteristic change in size and mass of the micelles is predicted. This can be used as a fingerprint to indirectly assess the spatial distribution. Based on these findings, we developed two experimental protocols to control and assess the spatial distribution of lyophobic compounds within block copolymer micelles.
UR - http://www.scopus.com/inward/record.url?scp=85063529553&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.9b00180
DO - 10.1021/acs.langmuir.9b00180
M3 - Article
C2 - 30811942
AN - SCOPUS:85063529553
SN - 0743-7463
VL - 35
SP - 4776
EP - 4786
JO - Langmuir
JF - Langmuir
IS - 13
ER -