Controlling the morphology of copolymeric vectors for next generation nanomedicine

D.S. Williams, I.A.B. Pijpers, R. Ridolfo, J.C.M. van Hest

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
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Abstract

Amidst the wealth of information that the past few decades of nanomedical research has given us there is one design principle that has emerged as being key for the success of delivery vectors: particle morphology. This review seeks to unpack the various facets of particlemorphology that are important for effective integration in vivo. In order to understand the contribution of morphology towards the biophysical function of nanovectors it is important to consider the historical development of such systems and how their physicochemical characteristics are selected. Ultimately, the purpose of this review is to give a clear perspective for the development of future nanovectors and how an integrated approach to their design, with particular focus upon their morphological features (size, shape, stimuli-responsiveness and surface chemistry), is vital for their performance in vitro and in vivo. (C) 2017 Published by Elsevier B.V.
Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalJournal of Controlled Release
Volume259
Issue number10 august 2016
DOIs
Publication statusPublished - 10 Aug 2017

Bibliographical note

Part of special issue:
4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2016), 23–26 September 2016, Suzhou, China

Keywords

  • Drug delivery
  • Nanomedicine
  • Nanoparticles
  • Nanovectors

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