Controlling the gelation temperature of biomimetic polyisocyanides

Paul H.J. Kouwer; Paula de Almeida; Onno van den Boomen; Zaskia H. Eksteen-Akeroyd; Roel Hammink; Maarten Jaspers; Stijn Kragt; Mathijs F.J. Mabesoone; Roeland J.M. Nolte; Alan E. Rowan; Martin G.T.A. Rutten; Vincent A.A. Le Sage; Daniel C. Schoenmakers; Chengfen Xing; Jialiang Xu

doi:10.1016/j.cclet.2017.11.002

Controlling the gelation temperature of biomimetic polyisocyanides

Paul H.J. Kouwer
, Paula de Almeida
, Onno van den Boomen
, Zaskia H. Eksteen-Akeroyd
, Roel Hammink
, Maarten Jaspers
, Stijn Kragt
, Mathijs F.J. Mabesoone
, Roeland J.M. Nolte
, Alan E. Rowan
, Martin G.T.A. Rutten
, Vincent A.A. Le Sage
, Daniel C. Schoenmakers
, Chengfen Xing
, Jialiang Xu

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Chinese Chemical Letters
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.cclet.2017.11.002
Publication status	Published - Feb 2018

Keywords

Smart materials
Lower critical solution temperature
Polyisocyanides
Mechanical properties
Biomimetic polymers

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10.1016/j.cclet.2017.11.002

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Kouwer, P. H. J., de Almeida, P., van den Boomen, O., Eksteen-Akeroyd, Z. H., Hammink, R., Jaspers, M., Kragt, S., Mabesoone, M. F. J., Nolte, R. J. M., Rowan, A. E., Rutten, M. G. T. A., Le Sage, V. A. A., Schoenmakers, D. C., Xing, C., & Xu, J. (2018). Controlling the gelation temperature of biomimetic polyisocyanides. Chinese Chemical Letters, 29(2), 281-284. https://doi.org/10.1016/j.cclet.2017.11.002

@article{aa2850b0d5b2406c8e3bbb0a9f334dbb,

title = "Controlling the gelation temperature of biomimetic polyisocyanides",

abstract = "Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.",

keywords = "Smart materials, Lower critical solution temperature, Polyisocyanides, Mechanical properties, Biomimetic polymers",

author = "Kouwer, \{Paul H.J.\} and \{de Almeida\}, Paula and \{van den Boomen\}, Onno and Eksteen-Akeroyd, \{Zaskia H.\} and Roel Hammink and Maarten Jaspers and Stijn Kragt and Mabesoone, \{Mathijs F.J.\} and Nolte, \{Roeland J.M.\} and Rowan, \{Alan E.\} and Rutten, \{Martin G.T.A.\} and \{Le Sage\}, \{Vincent A.A.\} and Schoenmakers, \{Daniel C.\} and Chengfen Xing and Jialiang Xu",

year = "2018",

month = feb,

doi = "10.1016/j.cclet.2017.11.002",

language = "English",

volume = "29",

pages = "281--284",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "2",

}

Kouwer, PHJ, de Almeida, P, van den Boomen, O, Eksteen-Akeroyd, ZH, Hammink, R, Jaspers, M, Kragt, S, Mabesoone, MFJ, Nolte, RJM, Rowan, AE, Rutten, MGTA, Le Sage, VAA, Schoenmakers, DC, Xing, C & Xu, J 2018, 'Controlling the gelation temperature of biomimetic polyisocyanides', Chinese Chemical Letters, vol. 29, no. 2, pp. 281-284. https://doi.org/10.1016/j.cclet.2017.11.002

TY - JOUR

T1 - Controlling the gelation temperature of biomimetic polyisocyanides

AU - Kouwer, Paul H.J.

AU - de Almeida, Paula

AU - van den Boomen, Onno

AU - Eksteen-Akeroyd, Zaskia H.

AU - Hammink, Roel

AU - Jaspers, Maarten

AU - Kragt, Stijn

AU - Mabesoone, Mathijs F.J.

AU - Nolte, Roeland J.M.

AU - Rowan, Alan E.

AU - Rutten, Martin G.T.A.

AU - Le Sage, Vincent A.A.

AU - Schoenmakers, Daniel C.

AU - Xing, Chengfen

AU - Xu, Jialiang

PY - 2018/2

Y1 - 2018/2

N2 - Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.

AB - Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.

KW - Smart materials

KW - Lower critical solution temperature

KW - Polyisocyanides

KW - Mechanical properties

KW - Biomimetic polymers

U2 - 10.1016/j.cclet.2017.11.002

DO - 10.1016/j.cclet.2017.11.002

M3 - Article

SN - 1001-8417

VL - 29

SP - 281

EP - 284

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 2

ER -

Controlling the gelation temperature of biomimetic polyisocyanides

Abstract

Keywords

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