Controlling the gelation temperature of biomimetic polyisocyanides

Paul H.J. Kouwer, Paula de Almeida, Onno van den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniel C. Schoenmakers, Chengfen Xing, Jialiang Xu

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.
LanguageEnglish
Pages281-284
Number of pages4
JournalChinese Chemical Letters
Volume29
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • Smart materials
  • Lower critical solution temperature
  • Polyisocyanides
  • Mechanical properties
  • Biomimetic polymers

Cite this

Kouwer, P. H. J., de Almeida, P., van den Boomen, O., Eksteen-Akeroyd, Z. H., Hammink, R., Jaspers, M., ... Xu, J. (2018). Controlling the gelation temperature of biomimetic polyisocyanides. Chinese Chemical Letters, 29(2), 281-284. DOI: 10.1016/j.cclet.2017.11.002
Kouwer, Paul H.J. ; de Almeida, Paula ; van den Boomen, Onno ; Eksteen-Akeroyd, Zaskia H. ; Hammink, Roel ; Jaspers, Maarten ; Kragt, Stijn ; Mabesoone, Mathijs F.J. ; Nolte, Roeland J.M. ; Rowan, Alan E. ; Rutten, Martin G.T.A. ; Le Sage, Vincent A.A. ; Schoenmakers, Daniel C. ; Xing, Chengfen ; Xu, Jialiang. / Controlling the gelation temperature of biomimetic polyisocyanides. In: Chinese Chemical Letters. 2018 ; Vol. 29, No. 2. pp. 281-284
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abstract = "Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.",
keywords = "Smart materials, Lower critical solution temperature, Polyisocyanides, Mechanical properties, Biomimetic polymers",
author = "Kouwer, {Paul H.J.} and {de Almeida}, Paula and {van den Boomen}, Onno and Eksteen-Akeroyd, {Zaskia H.} and Roel Hammink and Maarten Jaspers and Stijn Kragt and Mabesoone, {Mathijs F.J.} and Nolte, {Roeland J.M.} and Rowan, {Alan E.} and Rutten, {Martin G.T.A.} and {Le Sage}, {Vincent A.A.} and Schoenmakers, {Daniel C.} and Chengfen Xing and Jialiang Xu",
year = "2018",
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pages = "281--284",
journal = "Chinese Chemical Letters",
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Kouwer, PHJ, de Almeida, P, van den Boomen, O, Eksteen-Akeroyd, ZH, Hammink, R, Jaspers, M, Kragt, S, Mabesoone, MFJ, Nolte, RJM, Rowan, AE, Rutten, MGTA, Le Sage, VAA, Schoenmakers, DC, Xing, C & Xu, J 2018, 'Controlling the gelation temperature of biomimetic polyisocyanides' Chinese Chemical Letters, vol. 29, no. 2, pp. 281-284. DOI: 10.1016/j.cclet.2017.11.002

Controlling the gelation temperature of biomimetic polyisocyanides. / Kouwer, Paul H.J.; de Almeida, Paula; van den Boomen, Onno; Eksteen-Akeroyd, Zaskia H.; Hammink, Roel; Jaspers, Maarten; Kragt, Stijn; Mabesoone, Mathijs F.J.; Nolte, Roeland J.M.; Rowan, Alan E.; Rutten, Martin G.T.A.; Le Sage, Vincent A.A.; Schoenmakers, Daniel C.; Xing, Chengfen; Xu, Jialiang.

In: Chinese Chemical Letters, Vol. 29, No. 2, 02.2018, p. 281-284.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Controlling the gelation temperature of biomimetic polyisocyanides

AU - Kouwer,Paul H.J.

AU - de Almeida,Paula

AU - van den Boomen,Onno

AU - Eksteen-Akeroyd,Zaskia H.

AU - Hammink,Roel

AU - Jaspers,Maarten

AU - Kragt,Stijn

AU - Mabesoone,Mathijs F.J.

AU - Nolte,Roeland J.M.

AU - Rowan,Alan E.

AU - Rutten,Martin G.T.A.

AU - Le Sage,Vincent A.A.

AU - Schoenmakers,Daniel C.

AU - Xing,Chengfen

AU - Xu,Jialiang

PY - 2018/2

Y1 - 2018/2

N2 - Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.

AB - Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature (LCST) is often sharp, which allows for a wide range of smart material applications. At the LCST, oligo(ethylene glycol)-substituted polyisocyanides (PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol (EG) tails; every EG group increases the LCST and thus the gelation temperature by nearly 30 °C. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 °C and 60 °C and, consequently, tune the mechanical properties of the PIC gels.

KW - Smart materials

KW - Lower critical solution temperature

KW - Polyisocyanides

KW - Mechanical properties

KW - Biomimetic polymers

U2 - 10.1016/j.cclet.2017.11.002

DO - 10.1016/j.cclet.2017.11.002

M3 - Article

VL - 29

SP - 281

EP - 284

JO - Chinese Chemical Letters

T2 - Chinese Chemical Letters

JF - Chinese Chemical Letters

SN - 1001-8417

IS - 2

ER -

Kouwer PHJ, de Almeida P, van den Boomen O, Eksteen-Akeroyd ZH, Hammink R, Jaspers M et al. Controlling the gelation temperature of biomimetic polyisocyanides. Chinese Chemical Letters. 2018 Feb;29(2):281-284. Available from, DOI: 10.1016/j.cclet.2017.11.002