Controlled assembly of macromolecular β-sheet fibrils

J.M. Smeenk; M.B.J. Otten; J. Thies; D.A. Tirrell; H.G. Stunnenberg; J.C.M. Hest, van

doi:10.1002/anie.200462415

Controlled assembly of macromolecular β-sheet fibrils

J.M. Smeenk, M.B.J. Otten, J. Thies, D.A. Tirrell, H.G. Stunnenberg, J.C.M. Hest, van

Research output: Contribution to journal › Article › Academic › peer-review

140 Citations (Scopus)

Abstract

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)₃GluGly] _n sequence and poly(ethylene glycol) (PEG) of M_n = 750 g mol^-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

Original language	English
Pages (from-to)	1968-1971
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	13
DOIs	https://doi.org/10.1002/anie.200462415
Publication status	Published - 18 Mar 2005
Externally published	Yes

Keywords

Conjugation
Fibers
Peptides
Polymers
Self-assembly

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10.1002/anie.200462415

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AU - Stunnenberg, H.G.

AU - Hest, van, J.C.M.

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AB - Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

KW - Conjugation

KW - Fibers

KW - Peptides

KW - Polymers

KW - Self-assembly

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Controlled assembly of macromolecular β-sheet fibrils

Abstract

Keywords

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