Controlled assembly of macromolecular β-sheet fibrils

J.M. Smeenk, M.B.J. Otten, J. Thies, D.A. Tirrell, H.G. Stunnenberg, J.C.M. Hest, van

Research output: Contribution to journalArticleAcademicpeer-review

135 Citations (Scopus)

Abstract

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

Original languageEnglish
Pages (from-to)1968-1971
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number13
DOIs
Publication statusPublished - 18 Mar 2005
Externally publishedYes

Keywords

  • Conjugation
  • Fibers
  • Peptides
  • Polymers
  • Self-assembly

Fingerprint

Dive into the research topics of 'Controlled assembly of macromolecular β-sheet fibrils'. Together they form a unique fingerprint.

Cite this