Controlled assembly of macromolecular β-sheet fibrils

J.M. Smeenk, M.B.J. Otten, J. Thies, D.A. Tirrell, H.G. Stunnenberg, J.C.M. Hest, van

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Abstract

Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

Original languageEnglish
Pages (from-to)1968-1971
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number13
DOIs
Publication statusPublished - 18 Mar 2005
Externally publishedYes

Keywords

  • Conjugation
  • Fibers
  • Peptides
  • Polymers
  • Self-assembly

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    Smeenk, J. M., Otten, M. B. J., Thies, J., Tirrell, D. A., Stunnenberg, H. G., & Hest, van, J. C. M. (2005). Controlled assembly of macromolecular β-sheet fibrils. Angewandte Chemie - International Edition, 44(13), 1968-1971. https://doi.org/10.1002/anie.200462415