Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component

Libertario Demi; Ruud J. G. van Sloun; Hessel Wijkstra; Massimo Mischi

doi:10.1109/ULTSYM.2015.0303

Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component

Libertario Demi, Ruud J. G. van Sloun, Hessel Wijkstra, Massimo Mischi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Standard dynamic contrast-enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrastagent (UCA) concentration based on the amplitude of the harmonic components generated during ultrasound (US) propagation through UCAs. However, harmonic generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio (CTR) reduction, and resulting in possible tissue misclassification and misinterpretation of UCA concentrations. Especially for US tomography, no contrast-specific modality exists. Recently, a new marker for UCAs was discovered. A cumulative phase delay (CPD) between the second harmonic (2H) and fundamental (F0) component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, CPD based tomographic US images are presented and compared to standard US tomography. By testing its applicability on gelatin phantoms with cylindrical cavities filled with a SonoVue® UCA dilution, we showed that CPD tomography outperforms standard US tomography by speed of sound and dispersion analysis, yielding a superior CTR: 32.2 dB vs. 0.06 and 4.6 dB, respectively.

Original language	English
Title of host publication	2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan
Place of Publication	Piscataway
Publisher	Institute of Electrical and Electronics Engineers
Pages	1-4
DOIs	https://doi.org/10.1109/ULTSYM.2015.0303
Publication status	Published - 2015

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10.1109/ULTSYM.2015.0303

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Demi, L., van Sloun, R. J. G., Wijkstra, H., & Mischi, M. (2015). Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component. In 2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan (pp. 1-4). Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/ULTSYM.2015.0303

@inproceedings{fc95fb902d8a4b71ba2fad25cd6d7569,

title = "Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component",

abstract = "Standard dynamic contrast-enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrastagent (UCA) concentration based on the amplitude of the harmonic components generated during ultrasound (US) propagation through UCAs. However, harmonic generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio (CTR) reduction, and resulting in possible tissue misclassification and misinterpretation of UCA concentrations. Especially for US tomography, no contrast-specific modality exists. Recently, a new marker for UCAs was discovered. A cumulative phase delay (CPD) between the second harmonic (2H) and fundamental (F0) component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, CPD based tomographic US images are presented and compared to standard US tomography. By testing its applicability on gelatin phantoms with cylindrical cavities filled with a SonoVue{\textregistered} UCA dilution, we showed that CPD tomography outperforms standard US tomography by speed of sound and dispersion analysis, yielding a superior CTR: 32.2 dB vs. 0.06 and 4.6 dB, respectively.",

author = "Libertario Demi and {van Sloun}, {Ruud J. G.} and Hessel Wijkstra and Massimo Mischi",

year = "2015",

doi = "10.1109/ULTSYM.2015.0303",

language = "English",

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booktitle = "2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan",

publisher = "Institute of Electrical and Electronics Engineers",

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Demi, L, van Sloun, RJG , Wijkstra, H & Mischi, M 2015, Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component. in 2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan . Institute of Electrical and Electronics Engineers, Piscataway, pp. 1-4. https://doi.org/10.1109/ULTSYM.2015.0303

Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component. / Demi, Libertario; van Sloun, Ruud J. G.; Wijkstra, Hessel et al.
2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan . Piscataway: Institute of Electrical and Electronics Engineers, 2015. p. 1-4.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - Standard dynamic contrast-enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrastagent (UCA) concentration based on the amplitude of the harmonic components generated during ultrasound (US) propagation through UCAs. However, harmonic generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio (CTR) reduction, and resulting in possible tissue misclassification and misinterpretation of UCA concentrations. Especially for US tomography, no contrast-specific modality exists. Recently, a new marker for UCAs was discovered. A cumulative phase delay (CPD) between the second harmonic (2H) and fundamental (F0) component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, CPD based tomographic US images are presented and compared to standard US tomography. By testing its applicability on gelatin phantoms with cylindrical cavities filled with a SonoVue® UCA dilution, we showed that CPD tomography outperforms standard US tomography by speed of sound and dispersion analysis, yielding a superior CTR: 32.2 dB vs. 0.06 and 4.6 dB, respectively.

AB - Standard dynamic contrast-enhanced ultrasound (DCE-US) imaging detects and estimates ultrasound-contrastagent (UCA) concentration based on the amplitude of the harmonic components generated during ultrasound (US) propagation through UCAs. However, harmonic generation is not specific to UCAs, as it also occurs for US propagating through tissue. Moreover, nonlinear artifacts affect standard DCE-US imaging, causing contrast to tissue ratio (CTR) reduction, and resulting in possible tissue misclassification and misinterpretation of UCA concentrations. Especially for US tomography, no contrast-specific modality exists. Recently, a new marker for UCAs was discovered. A cumulative phase delay (CPD) between the second harmonic (2H) and fundamental (F0) component is in fact observable for US propagating through UCAs, and is absent in tissue. In this paper, CPD based tomographic US images are presented and compared to standard US tomography. By testing its applicability on gelatin phantoms with cylindrical cavities filled with a SonoVue® UCA dilution, we showed that CPD tomography outperforms standard US tomography by speed of sound and dispersion analysis, yielding a superior CTR: 32.2 dB vs. 0.06 and 4.6 dB, respectively.

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Demi L, van Sloun RJG , Wijkstra H , Mischi M. Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component. In 2015 IEEE International Ultrasonics Symposium (IUS), 21-24 October 2015, Taipei, Taiwan . Piscataway: Institute of Electrical and Electronics Engineers. 2015. p. 1-4 doi: 10.1109/ULTSYM.2015.0303

Contrast enhanced ultrasound tomography by means of the cumulative phase delay between second harmonic and fundamental component

Abstract

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