Abstract
During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.
| Original language | English |
|---|---|
| Pages (from-to) | 1186-1197 |
| Number of pages | 12 |
| Journal | Reaction Chemistry and Engineering |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Jul 2020 |
Funding
We kindly acknowledge funding by the H2020-FETOPEN-2016-2017 programme of the European Commission (Grant agreement number: 737266-ONE FLOW). Jan C. M. van Hest obtained his PhD from Eindhoven University of Technology in 1996 in macro- organic chemistry with Prof. E.W. Meijer. He worked as a postdoc with Prof. D. A. Tirrell on protein engineering. In 2000 he was appointed full professor in Bio- organic chemistry at Radboud University. As of September 2016 he holds the chair of Bio-organic Chemistry at Eindhoven University of Technology. He is recipient of an ERC Advanced grant and member of the Royal Netherlands Academy of Arts and Sciences. The group's focus is to develop well-defined compartments for nanomedicine and artificial cell research.
| Funders | Funder number |
|---|---|
| European Union's Horizon 2020 - Research and Innovation Framework Programme | 737266 |
| European Commission | |
| H2020 European Research Council | |
| Koninklijke Nederlandse Akademie van Wetenschappen |