Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R.L.J. Bloemendal, Mathilde A.C.H. Janssen, Jan C.M. van Hest (Corresponding author), Floris P.J.T. Rutjes (Corresponding author)

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)
79 Downloads (Pure)


During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

Original languageEnglish
Pages (from-to)1186-1197
Number of pages12
JournalReaction Chemistry and Engineering
Issue number7
Publication statusPublished - 1 Jul 2020


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