Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R.L.J. Bloemendal; Mathilde A.C.H. Janssen; Jan C.M. van Hest; Floris P.J.T. Rutjes

doi:10.1039/d0re00087f

Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Victor R.L.J. Bloemendal, Mathilde A.C.H. Janssen, Jan C.M. van Hest (Corresponding author), Floris P.J.T. Rutjes (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

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Abstract

During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

Original language	English
Pages (from-to)	1186-1197
Number of pages	12
Journal	Reaction Chemistry and Engineering
Volume	5
Issue number	7
DOIs	https://doi.org/10.1039/d0re00087f
Publication status	Published - 1 Jul 2020

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10.1039/d0re00087f

d0re00087fFinal published version, 6.08 MBLicence: TAVERNE

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title = "Continuous one-flow multi-step synthesis of active pharmaceutical ingredients",

abstract = "During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.",

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AU - Bloemendal, Victor R.L.J.

AU - Janssen, Mathilde A.C.H.

AU - van Hest, Jan C.M.

AU - Rutjes, Floris P.J.T.

PY - 2020/7/1

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N2 - During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

AB - During the past two decades, continuous flow chemistry has been developed into a mature field as shown by numerous examples in which complex molecules are synthesised. In this review we discuss recent one-flow multistep syntheses to produce active pharmaceutical ingredients (APIs) including challenges and solutions that have been encountered.

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U2 - 10.1039/d0re00087f

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JO - Reaction Chemistry and Engineering

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Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

Abstract

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