Construction and evaluation of an average CT brain image for inter-subject registration

C. Jongen, J.P.W. Pluim, P.J. Nederkoorn, M.A. Viergever, W.J. Niessen

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)


An average CT brain image is constructed to serve as reference frame for inter-subject registration. A set of 96 clinical CT images is used. Registration includes translation, rotation, and anisotropic scaling. A temporary average based on a subset of 32 images is constructed. This image is used as reference for the iterative construction of the average CT image. This approach is computationally efficient and results in a consistent registration of the 96 images. Registration of new images to the average CT is more consistent than registration to a single CT image. The use of the average CT image is illustrated. © 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)647-662
Number of pages16
JournalComputers in Biology and Medicine
Issue number8
Publication statusPublished - 2004


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