Confocal raman microspectroscopy: A new paradigm in the diagnosis of sensitive skin?

Denise Falcone, Natallia E. Uzunbajakava, Piet E.J. van Erp, Peter C.M. van de Kerkhof

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    Abstract

    Sensitive skin, a condition of subjective cutaneous hyperreactivity to various factors, is widespread in the industrialized world but still far from being well defined and completely understood (1). An impairment of the skin barrier function, located primarily in the stratum corneum (SC), is one of the key pathomechanisms considered to be involved in sensitive skin (2). Decreased thickness, imbalanced intercellular lipids, and decreased hydration have been associated with the SC of subjects with sensitive skin or hyperreactors (3,4). A causal pathway between the impairment of the skin barrier function, causing higher transcutaneous penetration of water-soluble chemicals, and skin hyperreactivity has been hypothesized (5).

    Original languageEnglish
    Title of host publicationSensitive Skin Syndrome, Second Edition
    PublisherCRC Press
    Pages73-82
    Number of pages10
    ISBN (Electronic)9781498737357
    ISBN (Print)9781498737340
    DOIs
    Publication statusPublished - 1 Jan 2017

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