Computer-aided classification of colorectal polyps using blue-light and linked-color imaging

T. Scheeve, Ramon-Michel Schreuder, F. van der Sommen, Joep E.G. IJspeert, Evelien Dekker, Erik J. Schoon, P.H.N. de With

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)


Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Since most CRCs develop from colorectal polyps (CRPs), accurate endoscopic differentiation facilitates decision making on resection of CRPs, thereby increasing cost-efficiency and reducing patient risk. Current classification systems based on whitelight imaging (WLI) or narrow-band imaging (NBI) have limited predictive power, or they do not consider sessile serrated adenomas/polyps (SSA/Ps), although these cause up to 30% of all CRCs. To better differentiate adenomas, hyperplastic polyps, and SSA/Ps, this paper explores the feasibility of two approaches: (1) an accurate computer-aided diagnosis (CADx) system for automated diagnosis of CRPs, and (2) novel endoscopic imaging techniques like blue-light imaging (BLI) and linked-color imaging (LCI). Two methods are explored to predict histology: (1) direct classification using a support vector machine (SVM) classifier, and (2) classification via a clinical classification model (WASP classification) combined with an SVM. The use of probabilistic features of SVM facilitates objective quantification of the detailed classification process. Automated differentiation of colonic polyp subtypes reaches accuracies of 78−96%, thereby improving medical expert results by 4−20%. Diagnostic accuracy for directly predicting adenomatous from hyperplastic histology reaches 93% and 87−90% using NBI and the novel BLI and LCI techniques, respectively, thus improving medical expert results by 26% and 20−23%, respectively. Predicting adenomatous histology in diminutive polyps with high confidence yields NPVs of 100%, clearly satisfying the PIVI guideline recommendation on endoscopic innovations (≥90% NPV). Our CADx system outperforms clinicians, while the novel BLI technique adds performance value.
Original languageEnglish
Title of host publicationMedical Imaging 2019: Computer-Aided Diagnosis
Subtitle of host publicationComputer-Aided Diagnosis
EditorsKensaku Mori, Horst K. Hahn
Place of PublicationBellingham
Number of pages8
ISBN (Electronic)9781510625471
Publication statusPublished - 13 Mar 2019
EventSPIE Medical Imaging 2019 - San Diego, United States
Duration: 16 Feb 201921 Feb 2019

Publication series

NameProceedings of SPIE
ISSN (Print)0277-786X


ConferenceSPIE Medical Imaging 2019
Country/TerritoryUnited States
CitySan Diego


  • Biomedical optical imaging
  • Classification
  • Colorectal polyps
  • Gastroenterology
  • Machine learning
  • colorectal polyps
  • gastroenterology
  • classification
  • biomedical optical imaging


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