Computed tomography detects tissue formation in a stented engineered heart Valve

L.M. de Heer, R.P.J. Budde, E.P.A. Vonken, F.P.T. Baaijens, P.F. Gründeman, L.A. van Herwerden, S.P. Hoerstrup, J. Kluin

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves.

Original languageEnglish
Pages (from-to)344-345
Number of pages2
JournalThe Annals of Thoracic Surgery
Issue number1
Publication statusPublished - Jul 2011


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