Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts

Sjeng Quicken, Yeshi de Bruin, Barend Mees, Jan Tordoir, Tammo Delhaas, Wouter Huberts (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear (OSI > 0.25) and very high wall shear stress (>40Pa) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.

Original languageEnglish
JournalBiomechanics and Modeling in Mechanobiology
DOIs
Publication statusE-pub ahead of print - 2 Nov 2019

Fingerprint

Polyurethanes
Dialysis
Veins
Hemodynamics
Grafts
Transplants
Compliance
Wall Shear Stress
Gold
Polytetrafluoroethylene
Polytetrafluoroethylenes
Disturbance
Fluid
Interaction
Fluid structure interaction
Simulation
Hyperplasia
Shear stress

Keywords

  • Dialysis graft
  • Fluid structure interaction modelling
  • Material choice
  • Polyurethane

Cite this

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title = "Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts",
abstract = "Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear (OSI > 0.25) and very high wall shear stress (>40Pa) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.",
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Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts. / Quicken, Sjeng; de Bruin, Yeshi; Mees, Barend; Tordoir, Jan; Delhaas, Tammo; Huberts, Wouter (Corresponding author).

In: Biomechanics and Modeling in Mechanobiology, 02.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Huberts, Wouter

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