Computational modeling of volumetric soft tissue growth : application to the cardiac left ventricle

J.W. Kroon, T. Delhaas, M.G.J. Arts, P.H.M. Bovendeerd

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65 Citations (Scopus)
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As an initial step to investigate stimulusresponserelations in growth and remodeling (G&R) of cardiac tissue, this study aims to develop a method to simulate 3D inhomogeneous volumetric growth. Growth is regarded as a deformation that is decomposed into a plastic component which describes unconstrained growth and an elastic component to satisfy continuity of the tissue after growth. In current growth models, a single reference configuration is used that remains fixed throughout the entire growth process.However, considering continuous turnover to occur together with growth, such a fixed reference is unlikely to exist in reality. Therefore, we investigated the effect of tissue turnoveron growth by incrementally updating the reference configuration. With both a fixed reference and an updated reference, strain-induced cardiac growth in magnitude of 30% could be simulated. However, with an updated reference, the amplitude of the stimulus for growth decreased over time, whereas with a fixed reference this amplitude increased. We conclude that, when modeling volumetric growth, the choice of the reference configuration is of great importance for the computed growth.
Original languageEnglish
Pages (from-to)301-309
JournalBiomechanics and Modeling in Mechanobiology
Issue number4
Publication statusPublished - 2009


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