Computational modeling of mitochondrial energy transduction

J.P.J. Schmitz, J. Vanlier, N.A.W. Riel, van, J.A.L. Jeneson

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)


    Mitochondria are the power plant of the heart, burning fat and sugars to supply the muscle with the adenosine triphosphate (ATP) free energy that drives contraction and relaxation during each heart beat. This function was first captured in a mathematical model in 1967. Today, interest in such a model has been rekindled by ongoing in silico integrative physiology efforts such as the Cardiac Physiome project. Here, the status of the field of computational modeling of mitochondrial ATP synthetic function is reviewed.
    Original languageEnglish
    Pages (from-to)363-377
    JournalCritical Reviews in Biomedical Engineering
    Issue number5
    Publication statusPublished - 2011


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