Computational modeling of cell orientation in 3D micro-constructs

Christine Obbink-Huizer, Cees W.J. Oomens, Sandra Loerakker, Jasper Foolen, Carlijn V.C. Bouten, Frank P.T. Baaijens

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

In many tissue engineering applications it is essential to understand how cells orient under the influence of their mechanical environment. In vitro engineered models are used to investigate the orientation of F-actin stress fibers inside cells. One such in vitro model [1] consists of a mixture of cells, collagen and matrigel, that is constrained by an array of silicone posts (Figure 1). We have recently developed a computational model to describe the orientation of stress fibers in response to their mechanical environment [2]. In the present study, this computational model is extended to 3D and used to simulate cell behavior in the mentioned in vitro model. This improves our understanding of how stress fibers orient in response to the mechanical environment and aids in optimizing the use of the in vitro model.
Original languageEnglish
Title of host publicationASME 2013 Summer Bioengineering Conference, SBC 2013
Number of pages2
Volume1 A
DOIs
Publication statusPublished - 1 Dec 2013
EventASME 2013 Summer Bioengineering Conference (SBC 2013) - Sunriver, United States
Duration: 26 Jun 201329 Jun 2013
http://www.asmeconferences.org/SBC2013/

Conference

ConferenceASME 2013 Summer Bioengineering Conference (SBC 2013)
Abbreviated titleSBC 2013
CountryUnited States
CitySunriver
Period26/06/1329/06/13
Internet address

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