TY - JOUR
T1 - Computational modeling for cardiovascular tissue engineering
T2 - the importance of including cell behavior in growth and remodeling algorithms
AU - Loerakker, Sandra
AU - Ristori, Tommaso
PY - 2020/9
Y1 - 2020/9
N2 - Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing robust cardiovascular tissue engineering strategies, which enable synthetic or biological scaffolds to transform into healthy living tissues after implantation. Computational modeling, particularly when integrated with experimental research, is key for advancing our understanding, predicting the in vivo evolution of engineered tissues, and efficiently optimizing scaffold designs. As cells are ultimately the drivers of G&R and known to change their behavior in response to mechanical cues, increasing efforts are currently undertaken to capture (mechano-mediated) cell behavior in computational models. In this selective review, we highlight some recent examples that are relevant in the context of cardiovascular tissue engineering and discuss the current and future biological and computational challenges for modeling cell-mediated G&R.
AB - Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing robust cardiovascular tissue engineering strategies, which enable synthetic or biological scaffolds to transform into healthy living tissues after implantation. Computational modeling, particularly when integrated with experimental research, is key for advancing our understanding, predicting the in vivo evolution of engineered tissues, and efficiently optimizing scaffold designs. As cells are ultimately the drivers of G&R and known to change their behavior in response to mechanical cues, increasing efforts are currently undertaken to capture (mechano-mediated) cell behavior in computational models. In this selective review, we highlight some recent examples that are relevant in the context of cardiovascular tissue engineering and discuss the current and future biological and computational challenges for modeling cell-mediated G&R.
KW - Cell signaling
KW - Computational modeling
KW - Cytoskeletal remodeling
KW - Growth and remodeling
KW - Migration
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85078006856&partnerID=8YFLogxK
U2 - 10.1016/j.cobme.2019.12.007
DO - 10.1016/j.cobme.2019.12.007
M3 - Review article
C2 - 33997580
AN - SCOPUS:85078006856
SN - 2468-4511
VL - 15
SP - 1
EP - 9
JO - Current Opinion in Biomedical Engineering
JF - Current Opinion in Biomedical Engineering
ER -