Urban physics is the science and engineering of physical processes in urban areas. It basically refers to the transfer of heat and mass in the outdoor and indoor urban environment, and its interaction with humans, fauna, flora and materials. Urban physics is a rapidly increasing focus area as it is key to understanding and addressing the grand societal challenges climate change, energy, health, security, transport and aging. The main assessment tools in urban physics are field measurements, full-scale and reduced-scale laboratory measurements and numerical simulation methods including Computational Fluid Dynamics (CFD). In the past 50 years, CFD has undergone a successful transition from an emerging field into an increasingly established field in urban physics research, practice and design. This review and position paper consists of two parts. In the first part, the importance of urban physics related to the grand societal challenges is described, after which the spatial and temporal scales in urban physics and the associated model categories are outlined. In the second part, based on a brief theoretical background, some views on CFD are provided. Possibilities and limitations are discussed, and in particular, ten tips and tricks towards accurate and reliable CFD simulations are presented. These tips and tricks are certainly not intended to be complete, rather they are intended to complement existing CFD best practice guidelines on ten particular aspects. Finally, an outlook to the future of CFD for urban physics is given.