Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

B. Vaz; S. Möcklinghoff; S. Folkertsma; S.J. Lusher; J. Vlieg, de; L. Brunsveld

doi:10.1039/B910677D

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

B. Vaz, S. Möcklinghoff, S. Folkertsma, S.J. Lusher, J. Vlieg, de, L. Brunsveld

Chemical Biology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

Original language	English
Pages (from-to)	5377-5379
Number of pages	3
Journal	Chemical Communications, ChemComm
Volume	2009
Issue number	36
DOIs	https://doi.org/10.1039/B910677D
Publication status	Published - 2009

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title = "Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics",

abstract = "Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.",

author = "B. Vaz and S. M{\"o}cklinghoff and S. Folkertsma and S.J. Lusher and {Vlieg, de}, J. and L. Brunsveld",

year = "2009",

doi = "10.1039/B910677D",

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publisher = "Royal Society of Chemistry",

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AU - Vaz, B.

AU - Möcklinghoff, S.

AU - Folkertsma, S.

AU - Lusher, S.J.

AU - Vlieg, de, J.

AU - Brunsveld, L.

PY - 2009

Y1 - 2009

N2 - Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

AB - Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.

U2 - 10.1039/B910677D

DO - 10.1039/B910677D

M3 - Article

SN - 1359-7345

VL - 2009

SP - 5377

EP - 5379

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

IS - 36

ER -

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

Abstract

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