Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

B. Vaz, S. Möcklinghoff, S. Folkertsma, S.J. Lusher, J. Vlieg, de, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure–activity relationship of such coactivator mimics concerning helix length.
Original languageEnglish
Pages (from-to)5377-5379
Number of pages3
JournalChemical Communications
Volume2009
Issue number36
DOIs
Publication statusPublished - 2009

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