Compression-induced damage and internal tissue strains are related

K.K. Ceelen, A. Stekelenburg, S. Loerakker, G.J. Strijkers, D.L. Bader, K. Nicolay, F.P.T. Baaijens, C.W.J. Oomens

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83 Citations (Scopus)
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Abstract

Prolonged mechanical loading of soft tissues adjacent to bony prominences can lead to degeneration of muscle tissue, resulting in a condition termed pressure-related deep tissue injury. This type of deep pressure ulcers can develop into a severe wound, associated with problematic healing and a variable prognosis. Limited knowledge of the underlying damage pathways impedes effective preventive strategies and early detection. Traditionally, pressure-induced ischemia has been thought to be the main etiological factor for initiating damage. Recent research, however, proposes tissue deformation per se as another candidate for initiating pressure-induced deep tissue injury. In this study, different strain parameters were evaluated on their suitability as a generic predictive indicator for deep tissue injury. With a combined animal-experimental numerical approach, we show that there is a reproducible monotonic increase in damage with increasing maximum shear strain once a strain threshold has been exceeded. This relationship between maximum shear strain and damage seems to reflect an intrinsic muscle property, as it applied across a considerable number of the experiments. This finding confirms that tissue deformation per se is important in the etiology of deep tissue injury. Using dedicated finite element modeling, a considerable reduction in the inherent biological variation was obtained, leading to the proposal that muscle deformation can prove a generic predictive indicator of damage
Original languageEnglish
Pages (from-to)3399-3404
JournalJournal of Biomechanics
Volume41
Issue number16
DOIs
Publication statusPublished - 2008

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