Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects

Mani Diba; Winston A. Camargo; Mariateresa Brindisi; Kambiz Farbod; Alexey Klymov; Stephan Schmidt; Matthew J. Harrington; Lorenza Draghi; Aldo R. Boccaccini; John A. Jansen; Jeroen J.J.P. van den Beucken; Sander C.G. Leeuwenburgh

doi:10.1002/adfm.201703438

Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects

Mani Diba, Winston A. Camargo, Mariateresa Brindisi, Kambiz Farbod, Alexey Klymov, Stephan Schmidt, Matthew J. Harrington, Lorenza Draghi, Aldo R. Boccaccini, John A. Jansen, Jeroen J.J.P. van den Beucken, Sander C.G. Leeuwenburgh (Corresponding author)

Biomedical Materials and Chemistry

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Abstract

Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.

Original language	English
Article number	1703438
Number of pages	12
Journal	Advanced Functional Materials
Volume	27
Issue number	45
DOIs	https://doi.org/10.1002/adfm.201703438
Publication status	Published - 1 Dec 2017

Funding

M.D. would like to thank Yang Zhang, Monique Kersten-Niessen, and Natasja van Dijk for their valuable suggestions and assistance with the experiments. M.D. would also like to thank Prof. Peter Fratzl and to acknowledge the travel award from the ICSHM2013 conference for supporting his research stay at the MPI-Potsdam. XL Sci-Tech, Inc. is acknowledged for providing the bioactive glass microspheres. This study was funded by the Netherlands Enterprise Agency through Project No. SHM012014 in the theme IOP Self Healing Materials.

Keywords

biomedical applications
colloids
composite materials
hydrogels
self-healing

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10.1002/adfm.201703438

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Diba, M., Camargo, W. A., Brindisi, M., Farbod, K., Klymov, A., Schmidt, S., Harrington, M. J., Draghi, L., Boccaccini, A. R., Jansen, J. A., van den Beucken, J. J. J. P., & Leeuwenburgh, S. C. G. (2017). Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects. Advanced Functional Materials, 27(45), Article 1703438. https://doi.org/10.1002/adfm.201703438

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title = "Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects",

abstract = "Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.",

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author = "Mani Diba and Camargo, {Winston A.} and Mariateresa Brindisi and Kambiz Farbod and Alexey Klymov and Stephan Schmidt and Harrington, {Matthew J.} and Lorenza Draghi and Boccaccini, {Aldo R.} and Jansen, {John A.} and {van den Beucken}, {Jeroen J.J.P.} and Leeuwenburgh, {Sander C.G.}",

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Diba, M, Camargo, WA, Brindisi, M, Farbod, K, Klymov, A, Schmidt, S, Harrington, MJ, Draghi, L, Boccaccini, AR, Jansen, JA, van den Beucken, JJJP & Leeuwenburgh, SCG 2017, 'Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects', Advanced Functional Materials, vol. 27, no. 45, 1703438. https://doi.org/10.1002/adfm.201703438

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AU - Camargo, Winston A.

AU - Brindisi, Mariateresa

AU - Farbod, Kambiz

AU - Klymov, Alexey

AU - Schmidt, Stephan

AU - Harrington, Matthew J.

AU - Draghi, Lorenza

AU - Boccaccini, Aldo R.

AU - Jansen, John A.

AU - van den Beucken, Jeroen J.J.P.

AU - Leeuwenburgh, Sander C.G.

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AB - Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.

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Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects

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