TY - JOUR
T1 - Composite colloidal gels made of bisphosphonate-functionalized gelatin and bioactive glass particles for regeneration of osteoporotic bone defects
AU - Diba, Mani
AU - Camargo, Winston A.
AU - Brindisi, Mariateresa
AU - Farbod, Kambiz
AU - Klymov, Alexey
AU - Schmidt, Stephan
AU - Harrington, Matthew J.
AU - Draghi, Lorenza
AU - Boccaccini, Aldo R.
AU - Jansen, John A.
AU - van den Beucken, Jeroen J.J.P.
AU - Leeuwenburgh, Sander C.G.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.
AB - Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonate-functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.
KW - biomedical applications
KW - colloids
KW - composite materials
KW - hydrogels
KW - self-healing
UR - http://www.scopus.com/inward/record.url?scp=85031399868&partnerID=8YFLogxK
U2 - 10.1002/adfm.201703438
DO - 10.1002/adfm.201703438
M3 - Article
AN - SCOPUS:85031399868
SN - 1616-301X
VL - 27
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 45
M1 - 1703438
ER -